ArticleJournal of contemporary brachytherapy2020
Does inverse planning improve plan quality in interstitial high-dose-rate breast brachytherapy?
Article in Journal of contemporary brachytherapy, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed, 9 citations in OpenAlex.
- Dosimetric comparison between manual and inverse optimization methods in high-dose-rate intracavitary/ interstitial cervical cancer brachytherapy for two treatment planning systems.Journal of contemporary brachytherapy · 2025Article
- Analysis of treatment planning time and optimization parameters for inverse planning for intracavitary and interstitial brachytherapy in uterine cervical cancer.Journal of applied clinical medical physics · 2025Article
- High-dose-rate Brachytherapy Planning with Dendrite Cross-Attention UNet.Proceedings of SPIE--the International Society for Optical Engineering · 2025Article
- The value of brachytherapy in the age of advanced external beam radiotherapy: a review of the literature in terms of dosimetry.Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al] · 2022Review
- Multicatheter interstitial brachytherapy versus stereotactic radiotherapy with CyberKnife for accelerated partial breast irradiation: a comparative treatment planning study with respect to dosimetry of organs at risk.Radiology and oncology · 2021Article
- Biological dose summation of external beam radiotherapy for the whole breast and image-guided high-dose-rate interstitial brachytherapy boost in early-stage breast cancer.Journal of contemporary brachytherapy · 2020Article
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeTo investigate the effect of input parameters for an inverse optimization algorithm, and dosimetrically evaluate and compare clinical treatment plans made by inverse and forward planning in high-dose-rate interstitial breast implants. MATERIAL AND
methodsBy using a representative breast implant, input parameters responsible for target coverage and dose homogeneity were changed step-by-step, and their optimal values were determined. Then, effects of parameters on dosimetry of normal tissue and organs at risk were investigated. The role of dwell time modulation restriction was also studied. With optimal input parameters, treatment plans of forty-two patients were re-calculated using an inverse optimization algorithm (HIPO). Then, a pair-wise comparison between forward and inverse plans was performed using dose-volume parameters.
resultsTo find a compromise between target coverage and dose homogeneity, we recommend using weight factors in the range of 70-90 for minimum dose, and in the range of 10-30 for maximum dose. Maximum dose value of 120% with a weight factor of 5 is recommended for normal tissue. Dose constraints for organs at risk did not play an important role, and the dwell time gradient restriction had only minor effect on target dosimetry. In clinical treatment plans, at identical target coverage, the inverse planning significantly increased the dose conformality (COIN, 0.75 vs. 0.69,
conclusionsBy using appropriate input parameters, inverse planning can provide dosimetrically superior dose distributions over forward planning in interstitial breast implants.
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