Evidence map›Paper›PMID 32395120›Full record

ArticleFrontiers in immunology2020

Langerhans Cells From Mice at Birth Express Endocytic- and Pattern Recognition-Receptors, Migrate to Draining Lymph Nodes Ferrying Antigen and Activate Neonatal T Cells

Miguel Angel Becerril-García, Juan Carlos Yam-Puc, Raúl Maqueda-Alfaro, Nonantzin Beristain-Covarrubias, Monica Heras-Chavarría, Isis Amara Gallegos-Hernández, Juana Calderón-Amador, Rosario Munguía-Fuentes, Luis Donis-Maturano, Adriana Flores-Langarica and 1 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in immunology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.3field-weighted citation impact, top 44% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 8 citations in OpenAlex.

  1. The roles of tissue resident macrophages in health and cancer.Experimental hematology & oncology · 2024
    Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 2 countries.

Miguel Angel Becerril-GarcíaDepartment of Cell Biology, Center for Advanced Research, The National Polytechnic Institute, Cinvestav-IPN, Mexico City, Mexico.
Juan Carlos Yam-PucDepartment of Cell Biology, Center for Advanced Research, The National Polytechnic Institute, Cinvestav-IPN, Mexico City, Mexico.
Raúl Maqueda-AlfaroDepartment of Cell Biology, Center for Advanced Research, The National Polytechnic Institute, Cinvestav-IPN, Mexico City, Mexico.
Nonantzin Beristain-CovarrubiasInstitute of Immunology and Immunotherapy, College of Medical and Dental Sciences, University of Birmingham, Birmingham, United Kingdom.
Monica Heras-ChavarríaDepartment of Cell Biology, Center for Advanced Research, The National Polytechnic Institute, Cinvestav-IPN, Mexico City, Mexico.
Isis Amara Gallegos-HernándezDepartment of Cell Biology, Center for Advanced Research, The National Polytechnic Institute, Cinvestav-IPN, Mexico City, Mexico.
Juana Calderón-AmadorDepartment of Cell Biology, Center for Advanced Research, The National Polytechnic Institute, Cinvestav-IPN, Mexico City, Mexico.
Rosario Munguía-FuentesDepartment of Cell Biology, Center for Advanced Research, The National Polytechnic Institute, Cinvestav-IPN, Mexico City, Mexico.
Luis Donis-MaturanoDepartment of Cell Biology, Center for Advanced Research, The National Polytechnic Institute, Cinvestav-IPN, Mexico City, Mexico.
Adriana Flores-LangaricaInstitute of Immunology and Immunotherapy, College of Medical and Dental Sciences, University of Birmingham, Birmingham, United Kingdom.
Leopoldo Flores-RomoDepartment of Cell Biology, Center for Advanced Research, The National Polytechnic Institute, Cinvestav-IPN, Mexico City, Mexico.
Center for Research and Advanced Studies of the National Polytechnic Institute · MXInstituto Politécnico Nacional · MXUniversity of Birmingham · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Antigen capturing at the periphery is one of the earliest, crucial functions of antigen-presenting cells (APCs) to initiate immune responses. Langerhans cells (LCs), the epidermal APCs migrate to draining lymph nodes (DLNs) upon acquiring antigens. An arsenal of endocytic molecules is available to this end, including lectins and pathogen recognition receptors (PRRs). However, cutaneous LCs are poorly defined in the early neonatal period. We assessed endocytic molecules expression

Indexed as

AnimalsAnimals, NewbornCell MovementCell ProliferationEpidermal CellsFemaleLangerhans CellsLymph NodesMiceMice, Inbred BALB CPregnancyReceptors, Cell SurfaceSkinT-LymphocytesTumor Necrosis Factor Receptor Superfamily, Member 7Receptors, Cell SurfaceTumor Necrosis Factor Receptor Superfamily, Member 7CD14CD204immunization at birthin vivo immune responseneonatesT cell activationTLR-4

Identifiers

PMID32395120
PMCPMC7197463
OpenAlexW3020133573

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.