Evidence map›Paper›PMID 32394995›Full record

ArticleMaterials & design2020

Homotypic targeting and drug delivery in glioblastoma cells through cell membrane-coated boron nitride nanotubes.

Daniele De Pasquale, Attilio Marino, Christos Tapeinos, Carlotta Pucci, Silvia Rocchiccioli, Elena Michelucci, Francesco Finamore, Liam McDonnell, Alice Scarpellini, Simone Lauciello and 4 more

Open access · goldAbstract read
In one paragraph

Article in Materials & design, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.

0numbers the graph read from it
0cells of the map it votes in
39citing papers in PubMed
6.0field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

39 citing papers in PubMed, 115 citations in OpenAlex.

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  20. Stimuli-Responsive Boron-Based Materials in Drug Delivery.International journal of molecular sciences · 2023
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 5 institutions in 2 countries.

Daniele De Pasquale *Istituto Italiano di Tecnologia, Smart Bio-Interfaces, Viale Rinaldo Piaggio 34, 56025 Pontedera, Italy.
Attilio Marino *Istituto Italiano di Tecnologia, Smart Bio-Interfaces, Viale Rinaldo Piaggio 34, 56025 Pontedera, Italy.
Christos TapeinosIstituto Italiano di Tecnologia, Smart Bio-Interfaces, Viale Rinaldo Piaggio 34, 56025 Pontedera, Italy.
Carlotta PucciIstituto Italiano di Tecnologia, Smart Bio-Interfaces, Viale Rinaldo Piaggio 34, 56025 Pontedera, Italy.
Silvia RocchiccioliNational Research Council, Institute of Clinical Physiology, Via Moruzzi 1, 56124 Pisa, Italy.
Elena MichelucciNational Research Council, Institute of Clinical Physiology, Via Moruzzi 1, 56124 Pisa, Italy.
Francesco FinamoreNational Research Council, Institute of Clinical Physiology, Via Moruzzi 1, 56124 Pisa, Italy.
Liam McDonnellFondazione Pisana per la Scienza - ONLUS, Via Ferruccio Giovannini 13, 56017 San Giuliano Terme, Italy.
Alice ScarpelliniIstituto Italiano di Tecnologia, Electron Microscopy Facility, Via Morego 30, 16163 Genova, Italy.
Simone LaucielloIstituto Italiano di Tecnologia, Electron Microscopy Facility, Via Morego 30, 16163 Genova, Italy.
Mirko PratoIstituto Italiano di Tecnologia, Materials Characterization Facility, Via Morego 30, 16163 Genova, Italy.
Aitor LarrañagaUniversity of the Basque Country, Department of Mining-Metallurgy Engineering and Materials Science & POLYMAT, Barrio Sarriena, 48013 Bilbao, Spain.
Filippo DragoIstituto Italiano di Tecnologia, Nanochemistry Department, Via Morego 30, 16163 Genova, Italy.
Gianni CiofaniIstituto Italiano di Tecnologia, Smart Bio-Interfaces, Viale Rinaldo Piaggio 34, 56025 Pontedera, Italy.
Piaggio (Italy) · ITItalian Institute of Technology · ITIstituto di Fisiologia Clinica · ITFondazione Pisa · ITUniversity of the Basque Country · ES

Funding

European Research Council 709613
6 · The paper itself

Abstract

Glioblastoma multiforme (GBM) is one of the most aggressive types of brain cancer, characterized by rapid progression, resistance to treatments, and low survival rates; the development of a targeted treatment for this disease is still today an unattained objective. Among the different strategies developed in the latest few years for the targeted delivery of nanotherapeutics, homotypic membrane-membrane recognition is one of the most promising and efficient. In this work, we present an innovative drug-loaded nanocarrier with improved targeting properties based on the homotypic recognition of GBM cells. The developed nanoplatform consists of boron nitride nanotubes (BNNTs) loaded with doxorubicin (Dox) and coated with cell membranes (CM) extracted from GBM cells (Dox-CM-BNNTs). We demonstrated as Dox-CM-BNNTs are able to specifically target and kill GBM cells

Indexed as

Boron nitride nanotubesCell-membrane coatingGlioblastoma multiformeHomotypic targeting

Identifiers

PMID32394995
PMCPMC7212088
OpenAlexW3020127270

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.