Evidence map›Paper›PMID 32394983›Full record

ArticleAustralian journal of chemistry2020

On-resin strategy to label α-conotoxins: Cy5-RgIA, a potent α9α10 nicotinic acetylcholine receptor imaging probe.

Markus Muttenthaler, Simon T Nevin, Marco Inserra, Richard J Lewis, David J Adams, Paul Alewood

Open access · greenAbstract read
In one paragraph

Article in Australian journal of chemistry, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.2field-weighted citation impact, top 46% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 7 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
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  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 3 countries.

Markus MuttenthalerInstitute for Molecular Bioscience, The University of Queensland, Brisbane, Australia.
Simon T NevinCentre for Advanced Imaging, The University of Queensland, Brisbane, Australia.
Marco InserraInstitute for Molecular Bioscience, The University of Queensland, Brisbane, Australia.
Richard J LewisInstitute for Molecular Bioscience, The University of Queensland, Brisbane, Australia.
David J AdamsIllawarra Health and Medical Research Institute, University of Wollongong, Wollongong, Australia.
Paul AlewoodInstitute for Molecular Bioscience, The University of Queensland, Brisbane, Australia.
University of Queensland · AUIllawarra Health and Medical Research Institute · AUUniversity of International Business · KZ

Funding

European Research Council 714366
6 · The paper itself

Abstract

In-solution conjugation is the most commonly used strategy to label peptides and proteins with fluorophores. However, lack of site-specific control and high costs of fluorophores are recognised limitations of this approach. Here, we established facile access to grams of Cy5-COOH

Indexed as

cyanine (Cy5) dyefluorescence imaging, molecular probeon-resin solid phase peptide synthesis (SPPS)α9α10 nicotinic acetylcholine receptor (nAChR)α-conotoxin α-RgIA

Identifiers

PMID32394983
PMCPMC7212043
OpenAlexW2993910708

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.