ArticleeLife2020
Local emergence in Amazonia of
Open access · goldAbstract read
In one paragraph
Article in eLife, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 93 papers.
0numbers the graph read from it
0cells of the map it votes in
93citing papers in PubMed
22.2field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
93 citing papers in PubMed, 184 citations in OpenAlex.
- Evaluation of a Bayesian hierarchical pharmacokinetic-pharmacodynamic model for predicting parasitological outcomes in Phase 2 studies of new antimalarial drugs.Antimicrobial agents and chemotherapy · 2024Trial
- Trial
- N8-Modified Quino[4,3,2-Kl]acridines as Promising Antimalarial G-Quadruplex Ligands.Chembiochem : a European journal of chemical biology · 2026Article
- Functional assessment of prevalentmBio · 2026Article
- Emergence of artemisinin-based combination therapy resistance markers inAntimicrobial agents and chemotherapy · 2026Article
- Antimalarial drug resistance inParasitology · 2026Article
- Review
- Global assessment of partial artemisinin resistance: multicenter trial across Kenya, Peru, and Thailand in patients with uncomplicated Plasmodium falciparum malaria.International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases · 2025Article
- Epigenetically conferred ring-stage survival in Plasmodium falciparum against artemisinin treatment.Nature communications · 2025Article
- Tracking Plasmodium falciparum antimalarial resistance markers during a malaria pre-elimination period in the Pacific coast of South America.Scientific reports · 2025Article
- Potential and pitfalls of using identity-by-descent for malaria genomic surveillance.Trends in parasitology · 2025Review
- Temporal Patterns of Haplotypic and Allelic Diversity Reflect the Changing Selection Landscape of the Malaria Parasite Plasmodium falciparum.Molecular biology and evolution · 2025Article
- Assessing fitness costs in malaria parasites: a comprehensive review and implications for drug resistance management.Malaria journal · 2025Review
- Sensitive and modular amplicon sequencing ofbioRxiv : the preprint server for biology · 2025Article
- YAT2150 is irresistible in Plasmodium falciparum and active against Plasmodium vivax and Leishmania clinical isolates.Scientific reports · 2025Article
- Changes in the malaria transmission profile in a low-endemic area of the Brazilian Amazon: a cause for concern.Revista do Instituto de Medicina Tropical de Sao Paulo · 2025Article
- Artemisinin-resistant malaria.Clinical microbiology reviews · 2024Review
- Population genomics and transcriptomics of Plasmodium falciparum in Cambodia and Vietnam uncover key components of the artemisinin resistance genetic background.Nature communications · 2024Article
- In vitro evaluation of ganaplacide/lumefantrine combination against Plasmodium falciparum in a context of artemisinin resistance.The Journal of antimicrobial chemotherapy · 2024Article
- Article
33 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
16 authors at 8 institutions in 4 countries.
Luana C MathieuLaboratoire de parasitologie, Centre Nationale de Référence du Paludisme, World Health Organization Collaborating Center for surveillance of antimalarial drug resistance, Institut Pasteur de la Guyane, Cayenne, French Guiana.ORCID 0000-0002-6021-468X
Horace CoxMinistry of Public Health, Georgetown, Guyana.
Angela M Early *Broad Institute of MIT and Harvard, Cambridge, United States.
Sachel Mok *Department of Microbiology and Immunology, Columbia University Irving Medical Center, New York, United States.ORCID 0000-0002-9605-0154
Yassamine LazrekLaboratoire de parasitologie, Centre Nationale de Référence du Paludisme, World Health Organization Collaborating Center for surveillance of antimalarial drug resistance, Institut Pasteur de la Guyane, Cayenne, French Guiana.
Jeanne-Celeste PaquetDepartment of Microbiology and Immunology, Columbia University Irving Medical Center, New York, United States.ORCID 0000-0001-6046-0154
Maria-Paz AdeDepartment of Communicable Diseases and Environmental Determinants of Health, Pan American Health Organization/World Health Organization, Washington, United States.
Naomi W LucchiMalaria Branch, Division of Parasitic Diseases and Malaria, Center for Global Health, Centers for Disease Control and Prevention, Atlanta, United States.
Quacy GrantMinistry of Public Health, Georgetown, Guyana.
Venkatachalam UdhayakumarMalaria Branch, Division of Parasitic Diseases and Malaria, Center for Global Health, Centers for Disease Control and Prevention, Atlanta, United States.
Jean Sf AlexandrePan American Health Organization, Georgetown, Guyana.
Magalie DemarService de Maladies Infectieuses et Tropicales, Centre Hospitalier Andrée Rosemon, Cayenne, French Guiana.
Pascal RingwaldGlobal Malaria Program, World Health Organization, Geneva, Switzerland.
Daniel E Neafsey *Broad Institute of MIT and Harvard, Cambridge, United States.ORCID 0000-0002-1665-9323
David A Fidock *Department of Microbiology and Immunology, Columbia University Irving Medical Center, New York, United States.ORCID 0000-0001-6753-8938
Lise MussetLaboratoire de parasitologie, Centre Nationale de Référence du Paludisme, World Health Organization Collaborating Center for surveillance of antimalarial drug resistance, Institut Pasteur de la Guyane, Cayenne, French Guiana.ORCID 0000-0003-0215-4110
Columbia University Irving Medical Center · USUniversity of Guyana · GYBroad Institute · USCenters for Disease Control and Prevention · USInstitut Pasteur de la Guyane · GFUniversity of French Guiana · GFWorld Health Organization · CHWorld Health Organization Regional Office for the Americas · US
Funding
Viral Genomics: evolution, spread, and host interactionsU19AI110818 · NIAID · BROAD INSTITUTE, INC. · PI NEAFSEY, DANIEL E · 2014 to 2024
$66.5MDefining the Role of PfCRT and PfMDR1 as Pleiotropic Mediators of Plasmodium falciparum Multidrug ResistanceR37AI050234 · NIAID · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI David A Fidock · 2018 to 2026
$4.4MDefining P. falciparum resistance to artemisinin-based combination therapiesR01AI109023 · NIAID · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI FIDOCK, DAVID A · 2014 to 2025
$4.4MElucidating the molecular basis of piperaquine resistance in Plasmodium falciparumR01AI124678 · NIAID · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI David A Fidock · 2016 to 2026
$4.3MAgence Nationale de la Recherche ANR-10-LABX-25-01Bill and Melinda Gates Foundation OPP1201387European Commission GY0012082National Institute of Allergy and Infectious Diseases U19AI110818NIAID NIH HHS R01 AI109023NIAID NIH HHS R01 AI124678NIAID NIH HHS R37 AI050234NIAID NIH HHS U19 AI110818NIH HHS R01 124678NIH HHS R01 AI109023NIH HHS R37 AI50234U.S. Department of Defense W81XWH1910086World Health Organization 001
Abstract
Antimalarial drug resistance has historically arisen through convergent
Indexed as
AntimalarialsArtemisininsDrug ResistanceGenes, ProtozoanGenetic FitnessGuyanaHaplotypesHumansMalaria, FalciparumMutationPlasmodium falciparumProtozoan ProteinsWhole Genome SequencingAntimalarialsArtemisininsProtozoan Proteinsartemisinin resistanceepidemiologyevolutionglobal healthGuyanainfectious diseasekelch 13malariamicrobiologyP. falciparumSouth America
Identifiers
What OpenQuestion holds
Textmetadata
LicenceCC BY
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.