Evidence map›Paper›PMID 32394845›Full record

ReviewAnti-inflammatory & anti-allergy agents in medicinal chemistry2021

Dietary Technologies to Optimize Healing from Injury-Induced Inflammation.

Barry Sears, Mary Perry, Asish K Saha

Abstract readReview
In one paragraph

Review in Anti-inflammatory & anti-allergy agents in medicinal chemistry, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Barry SearsInflammation Research Foundation, Peabody, MA 01960, United States.
Mary PerryInflammation Research Foundation, Peabody, MA 01960, United States.
Asish K SahaInflammation Research Foundation, Peabody, MA 01960, United States.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Inflammation is an acute adaptive response to injury. However, if the initial inflammatory response to an injury is not completely healed, it becomes chronic low-level inflammation that is strongly associated with many chronic disease states, including metabolic (obesity and diabetes), cardiovascular, auto-immune, and neurogenerative disorders as well as cancer. The healing process is far more complex than the initiation of inflammation. Within that complexity of healing is a sequence of events that are under profound dietary control and can be defined by specific blood markers. Those molecular events of the healing process that are under significant dietary control are termed as the Resolution Response. The purpose of this review is to describe the molecular components of the Resolution Response and how different dietary factors can either optimize or inhibit their actions. In particular, those dietary components that optimize the Resolution Response include a calorie-restricted, protein-adequate, moderate-carbohydrate, low-fat diet referred to as the Zone diet, omega-3 fatty acids, and polyphenols. The appropriate combination of these dietary interventions constitutes the foundation of Pro-Resolution Nutrition. The effect of these dietary components the actions of NF-κB, AMPK, eicosanoids, and resolvins are described in this review, as well as ranges of appropriate blood markers that indicate success in optimizing the Resolution Response by dietary interventions.

Indexed as

DietAMP-Activated Protein KinasesDietary CarbohydratesDietary FatsDietary ProteinsEicosanoidsEndoplasmic ReticulumEnergy IntakeFatty Acids, Omega-3InflammasomesInflammationMetabolic SyndromeNF-kappa BWounds and InjuriesAMP-Activated Protein KinasesDietary CarbohydratesDietary FatsDietary ProteinsEicosanoidsFatty Acids, Omega-3InflammasomesNF-kappa BAMPKeicosanoidsinflammationNF-κBomega-3 fatty acidspolyphenolsResolution responseresolvinszone diet

Identifiers

PMID32394845
PMCPMC9906631

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.