Evidence map›Paper›PMID 32394805›Full record

ArticleJournal of neurotrauma2020

Vascular-Cognitive Impairment following High-Thoracic Spinal Cord Injury Is Associated with Structural and Functional Maladaptations in Cerebrovasculature.

Rahul Sachdeva, Mengyao Jia, Shaoxun Wang, Andrew Yung, Mei Mu Zi Zheng, Amanda H X Lee, Aaron Monga, Sarah Leong, Piotr Kozlowski, Fan Fan and 3 more

Open access · greenAbstract read
In one paragraph

Article in Journal of neurotrauma, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 1 pooled it
1.2field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 1 synthesis or guideline pooled it, 20 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Dysreflexic dilemma: do we need a revised definition for autonomic dysreflexia?Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2025
    Article
  4. Article
  5. Cerebrovascular Reactivity Following Spinal Cord Injury.Topics in spinal cord injury rehabilitation · 2024
    Article
  6. Article
  7. Article
  8. Neurovascular Coupling in Development and Disease: Focus on Astrocytes.Frontiers in cell and developmental biology · 2021
    Review
  9. Article
  10. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 3 institutions in 2 countries.

Rahul SachdevaInternational Collaboration on Repair Discoveries, Vancouver, British Columbia, Canada.
Mengyao JiaInternational Collaboration on Repair Discoveries, Vancouver, British Columbia, Canada.
Shaoxun WangDepartment of Pharmacology and Toxicology, The University of Mississippi Medical Center, Jackson, Mississippi, USA.
Andrew YungInternational Collaboration on Repair Discoveries, Vancouver, British Columbia, Canada.
Mei Mu Zi ZhengInternational Collaboration on Repair Discoveries, Vancouver, British Columbia, Canada.
Amanda H X LeeInternational Collaboration on Repair Discoveries, Vancouver, British Columbia, Canada.
Aaron MongaInternational Collaboration on Repair Discoveries, Vancouver, British Columbia, Canada.
Sarah LeongUniversity of British Columbia, Vancouver, British Columbia, Canada.
Piotr KozlowskiInternational Collaboration on Repair Discoveries, Vancouver, British Columbia, Canada.
Fan FanDepartment of Pharmacology and Toxicology, The University of Mississippi Medical Center, Jackson, Mississippi, USA.
Richard J RomanDepartment of Pharmacology and Toxicology, The University of Mississippi Medical Center, Jackson, Mississippi, USA.
Aaron A PhillipsDepartments of Physiology and Pharmacology, University of Calgary, Calgary, Alberta, Canada.
Andrei V KrassioukovInternational Collaboration on Repair Discoveries, Vancouver, British Columbia, Canada.
University of British Columbia · CAUniversity of Mississippi Medical Center · USUniversity of Calgary · CA

Funding

Role of obesity in preeclamptic pregnancy.P20GM121334 · NIGMS · UNIVERSITY OF MISSISSIPPI MED CTR · PI Babbette LaMarca, Jane F Reckelhoff · 2017 to 2026
$26.4M
The role of leptin in autoimmune-associated hypertensionP20GM104357 · NIGMS · UNIVERSITY OF MISSISSIPPI MED CTR · PI TAYLOR, ERIN BASSFORD · 2013 to 2022
$23.4M
Genetic determinants of hypertension-induced cerebral vascular dysfunctionR01HL138685 · NHLBI · UNIVERSITY OF MISSISSIPPI MED CTR · PI ROMAN, RICHARD J. · 2018 to 2021
$1.9M
Adducin, actin cytoskeleton and cognitive impairmentsR01AG057842 · NIA · UNIVERSITY OF MISSISSIPPI MED CTR · PI WILLIAMS, JAN MICHAEL · 2019 to 2023
$1.9M
Renal microcirculation and hypertension induced renal injuryR01DK104184 · NIDDK · UNIVERSITY OF MISSISSIPPI MED CTR · PI ROMAN, RICHARD J. · 2014 to 2017
$1.8M
Animal model of impaired autoregulation for study of age related vascular cognitive impairmentR21AG050049 · NIA · UNIVERSITY OF MISSISSIPPI MED CTR · PI FAN, FAN · 2016 to 2017
$419k
CIHR 159573CIHR 389694CIHR 415366NHLBI NIH HHS R01 HL138685NIA NIH HHS R01 AG057842NIA NIH HHS R21 AG050049NIDDK NIH HHS R01 DK104184NIGMS NIH HHS P20 GM104357NIGMS NIH HHS P20 GM121334
6 · The paper itself

Abstract

Individuals living with chronic spinal cord injury (SCI) often exhibit impairments in cognitive function, which impede their rehabilitation and transition into the community. Although a number of clinical studies have demonstrated the impact of impaired cardiovascular control on cognitive impairment, the mechanistic understanding of this deleterious relationship is still lacking. The present study investigates whether chronic disruption of cardiovascular control following experimental SCI results in cerebrovascular decline and vascular cognitive impairment. Fourteen weeks following a high thoracic SCI (at the third thoracic segment), rats were subjected to a battery of

Indexed as

AnimalsCerebrovascular CirculationCholinergic AgonistsCognitive DysfunctionEndothelium, VascularMaleMiddle Cerebral ArteryRatsRats, WistarSpinal Cord InjuriesThoracic VertebraeVasodilationCholinergic Agonistscerebrovascular deficitcognitive impairmentendothelial dysfunctionspinal cord injuryvascular fibrosis

Identifiers

PMID32394805
PMCPMC7470217
OpenAlexW3025150186

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.