Evidence map›Paper›PMID 32394777›Full record

Trial reportJournal of the American Heart Association2020

Randomized Trial of Combined Aerobic, Resistance, and Cognitive Training to Improve Recovery From Stroke: Feasibility and Safety.

Sebastian Koch, Eduard Tiozzo, Marialaura Simonetto, David Loewenstein, Clinton B Wright, Chuanhui Dong, Antonio Bustillo, Miguel Perez-Pinzon, Kunjan R Dave, Carolina M Gutierrez and 8 more

Open access · goldAbstract readRandomized Controlled Trial
In one paragraph

Trial report in Journal of the American Heart Association, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed, 5 pooled it
1.5field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 5 syntheses or guidelines pooled it, 34 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Pooled it
  5. Occupational therapy for cognitive impairment in stroke patients.The Cochrane database of systematic reviews · 2022
    Pooled it
  6. Trial
  7. Review
  8. Article
  9. Article
  10. Review
  11. Review
  12. Article
  13. Article
  14. Article
  15. Article
  16. Efficacy of mechanisms of neuroplasticity after a stroke.Restorative neurology and neuroscience · 2022
    Article
  17. Article
  18. Review
  19. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors at 2 institutions in 1 country.

Sebastian KochDepartment of Neurology Miller School of Medicine University of Miami FL.
Eduard TiozzoDepartment of Physical Medicine and Rehabilitation Miller School of Medicine University of Miami FL.
Marialaura SimonettoDepartment of Neurology Miller School of Medicine University of Miami FL.
David LoewensteinDepartment of Physical Medicine and Rehabilitation Miller School of Medicine University of Miami FL.
Clinton B WrightNational Institute of Neurological Disorders and Stroke (NINDS) Bethesda MD.
Chuanhui DongDepartment of Neurology Miller School of Medicine University of Miami FL.
Antonio BustilloDepartment of Neurology Miller School of Medicine University of Miami FL.
Miguel Perez-PinzonDepartment of Neurology Miller School of Medicine University of Miami FL.
Kunjan R DaveDepartment of Neurology Miller School of Medicine University of Miami FL.
Carolina M GutierrezDepartment of Neurology Miller School of Medicine University of Miami FL.
John E LewisDepartment of Physical Medicine and Rehabilitation Miller School of Medicine University of Miami FL.
Marti FlothmannDepartment of Neurology Miller School of Medicine University of Miami FL.
M Carolina Mendoza-PucciniNational Institute of Neurological Disorders and Stroke (NINDS) Bethesda MD.
Barbara JuncoDepartment of Neurology Miller School of Medicine University of Miami FL.
Zuzel RodriguezDepartment of Neurology Miller School of Medicine University of Miami FL.
Joyce Gomes-OsmanDepartment of Physical Medicine and Rehabilitation Miller School of Medicine University of Miami FL.
Tatjana RundekDepartment of Neurology Miller School of Medicine University of Miami FL.
Ralph L SaccoDepartment of Neurology Miller School of Medicine University of Miami FL.
University of Miami · USNational Institute of Neurological Disorders and Stroke · US

Funding

Institutional Career Development CoreKL2TR002737 · NCATS · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI RUNDEK, TATJANA, SCOTT, GWENDOLYN BARBARA · 2018 to 2022
$3.6M
NCATS NIH HHS KL2 TR002737
6 · The paper itself

Abstract

Background Physical exercise and cognitive training have been recommended to improve cognitive outcomes poststroke, but a multifaceted strategy including aerobic, resistance, and cognitive training to facilitate poststroke recovery has not been investigated. We aimed to assess the feasibility, adherence, and safety of a combined aerobic, resistance, and cognitive training intervention (CARET+CTI) after stroke. Methods and Results We prospectively randomized patients presenting with recent stroke to a comparison of a supervised 12-week CARET+CTI program and a control group receiving sham CARET+CTI. Participants were scheduled for 3 weekly CARET and CTI sessions. All participants underwent pre- and postintervention assessments of strength, endurance, and cognition. The primary outcomes were feasibility and adherence, defined as the ratio of scheduled and observed visits, and safety. We enrolled 131 participants, of whom 37 withdrew from the study. There were 17 (20%) withdrawals in the CARET+CTI and 20 (44%) in the control group. The observed-over-expected visit ratio was significantly higher in the intervention than in the control group (0.74±0.30 versus 0.54±0.38;

Indexed as

CognitionCognitive Behavioral TherapyResistance TrainingStroke RehabilitationAffectAgedCombined Modality TherapyDisability EvaluationFeasibility StudiesFemaleFloridaFunctional StatusHumansMaleMental HealthMiddle Agedcognitive trainingexerciserandomized clinical trialstroke recovery

Identifiers

PMID32394777
PMCPMC7660866
OpenAlexW3024967608

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.