Evidence map›Paper›PMID 32394352›Full record

ArticleJournal of cardiovascular translational research2020

3D-Printed Coronary Implants Are Effective for Percutaneous Creation of Swine Models with Focal Coronary Stenosis.

Caroline M Colbert, Jiaxin Shao, John J Hollowed, Jesse W Currier, Olujimi A Ajijola, Gregory A Fishbein, Sandra M Duarte-Vogel, Rohan Dharmakumar, Peng Hu, Kim-Lien Nguyen

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of cardiovascular translational research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.3field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

Caroline M ColbertPhysics and Biology in Medicine Graduate Program, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA.
Jiaxin ShaoDiagnostic Cardiovascular Imaging Laboratory, Department of Radiological Sciences, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA.
John J HollowedDivision of Cardiology, David Geffen School of Medicine at UCLA and VA Greater Los Angeles Healthcare System, 11301 Wilshire Blvd, MC 111E, Los Angeles, CA, 90073, USA.
Jesse W CurrierDivision of Cardiology, David Geffen School of Medicine at UCLA and VA Greater Los Angeles Healthcare System, 11301 Wilshire Blvd, MC 111E, Los Angeles, CA, 90073, USA.
Olujimi A AjijolaUCLA Cardiac Arrhythmia Center and Division of Cardiology, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA.
Gregory A FishbeinDepartment of Pathology, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA.
Sandra M Duarte-VogelDivision of Laboratory Animal Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA.
Rohan DharmakumarBiomedical Imaging Research Institute, Department of Biomedical Sciences, Cedars-Sinai Medical Center and Department of Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA.
Peng HuPhysics and Biology in Medicine Graduate Program, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA.
Kim-Lien NguyenPhysics and Biology in Medicine Graduate Program, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA. klnguyen@ucla.edu.ORCID http://orcid.org/0000-0002-8854-2976
University of California, Los Angeles · USVA Greater Los Angeles Healthcare System · USCedars-Sinai Medical Center · US

Funding

Expanding on a new paradigm for MRI in pediatric congenital heart diseaseR01HL127153 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI CHRISTODOULOU, ANTHONY G, FINN, JOHN PAUL · 2015 to 2024
$6.1M
Developing a MRI-guided Disease-Modifying Therapy for Post Infarction Chronic Heart FailureR01HL133407 · NHLBI · INDIANA UNIVERSITY INDIANAPOLIS · PI Rohan Dharmakumar · 2017 to 2026
$4.9M
Ferumoxytol-Enhanced Cardiac MRI for Ischemic Heart DiseaseR01HL148182 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI NGUYEN, KIM-LIEN T · 2020 to 2024
$3.8M
An Accurate Non-Contrast-Enhanced Cardiac MRI Method for Imaging Chronic Myocardial Infarctions: Technical Developments to Rapid Clinical ValidationR01HL136578 · NHLBI · CEDARS-SINAI MEDICAL CENTER · PI LI, DEBIAO · 2017 to 2020
$3.4M
Mechanistic Insights to A Translatable Therapy for Acute Reperfused Hemorrhagic Myocardial InfarctionsR01HL147133 · NHLBI · INDIANA UNIVERSITY INDIANAPOLIS · PI DHARMAKUMAR, ROHAN, FRANCIS, JOSEPH · 2020 to 2023
$3.2M
Mechanisms of Cardiac Dysfunction in HIV and the Effect of StatinsR01HL137562 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI NEILAN, TOMAS G, ZANNI, MARKELLA V. · 2017 to 2020
$2.7M
Multimodal Decoding of the Neural Circuitry of Sudden Death in Peripheral GangliaDP2HL142045 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI AJIJOLA, OLUJIMI A · 2017 to 2017
$2.3M
Tailoring Stress Cardiac MRI for Women with Ischemic Heart DiseaseI01CX001901 · VA · VA GREATER LOS ANGELES HEALTHCARE SYSTEM · PI NGUYEN, KIM-LIEN T · 2019 to 2025
–
American Heart Association-American Stroke Association 18TPA34170049CSRD VA I01 CX001901NHLBI NIH HHS DP2 HL142045NHLBI NIH HHS R01 HL127153NHLBI NIH HHS R01 HL133407NHLBI NIH HHS R01 HL136578NHLBI NIH HHS R01 HL137562NHLBI NIH HHS R01 HL147133NHLBI NIH HHS R01 HL148182
6 · The paper itself

Abstract

Reliable, closed-chest methods for creating large animal models of acute myocardial hypoperfusion are limited. We demonstrated the feasibility and efficacy of using magnetic resonance (MR)-compatible 3D-printed coronary implants for establishing swine models of myocardial hypoperfusion. We designed, manufactured, and percutaneously deployed implants in 13 swine to selectively create focal coronary stenosis. To test the efficacy of the implants to cause hypoperfusion or ischemia in the perfused territory, we evaluated regional wall motion, myocardial perfusion, and infarction using MR imaging. The overall swine survival rate was 85% (11 of 13). The implant retrieval rate was 92% (12 of 13). Fluoroscopic angiography confirmed focal stenosis. Cine and perfusion MRI showed regional wall motion abnormalities and inducible ischemia, respectively. Late gadolinium enhancement and histopathology showed no myocardial infarction. Our minimally invasive technique has promising applications for validation of new diagnostic methods in cardiac MR. Graphical abstract Our new minimally invasive, percutaneous method for creating swine models of acute focal coronary stenosis can be used for magnetic resonance imaging studies of myocardial ischemia. Comparable to existing methods in its efficacy and reliability, this rapid prototyping technique will allow researchers to more easily conduct translational cardiac imaging studies of coronary artery disease in large animal models.

Indexed as

Printing, Three-DimensionalProsthesis DesignAnimalsCoronary CirculationCoronary StenosisDisease Models, AnimalFeasibility StudiesMagnetic Resonance Imaging, CineMaleMyocardial InfarctionMyocardial Perfusion ImagingProof of Concept StudyProsthesis ImplantationSus scrofa3D printingAcute swine modelIschemic heart diseaseMinimally invasiveMRIStress testing

Identifiers

PMID32394352
PMCPMC9667863
OpenAlexW3025817760

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.