Evidence map›Paper›PMID 32394277›Full record

ArticleNeuroscience bulletin2020

Responses of Primary Afferent Fibers to Acupuncture-Like Peripheral Stimulation at Different Frequencies: Characterization by Single-Unit Recording in Rats.

Ran Huo, Song-Ping Han, Feng-Yu Liu, Xiao-Jing Shou, Ling-Yu Liu, Tian-Jia Song, Fu-Jun Zhai, Rong Zhang, Guo-Gang Xing, Ji-Sheng Han

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In one paragraph

Article in Neuroscience bulletin, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Ran HuoNeuroscience Research Institute, Peking University, Beijing, 100191, China.
Song-Ping HanNeuroscience Research Institute, Peking University, Beijing, 100191, China.
Feng-Yu LiuNeuroscience Research Institute, Peking University, Beijing, 100191, China.
Xiao-Jing ShouNeuroscience Research Institute, Peking University, Beijing, 100191, China.
Ling-Yu LiuNeuroscience Research Institute, Peking University, Beijing, 100191, China.
Tian-Jia SongNeuroscience Research Institute, Peking University, Beijing, 100191, China.
Fu-Jun ZhaiNeuroscience Research Institute, Peking University, Beijing, 100191, China.
Rong ZhangNeuroscience Research Institute, Peking University, Beijing, 100191, China.
Guo-Gang XingNeuroscience Research Institute, Peking University, Beijing, 100191, China. ggxing@bjmu.edu.cn.
Ji-Sheng HanNeuroscience Research Institute, Peking University, Beijing, 100191, China. hanjisheng@bjmu.edu.cn.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The pain-relieving effect of acupuncture is known to involve primary afferent nerves (PANs) via their roles in signal transmission to the CNS. Using single-unit recording in rats, we characterized the generation and transmission of electrical signals in Aβ and Aδ fibers induced by acupuncture-like stimuli. Acupuncture-like signals were elicited in PANs using three techniques: manual acupuncture (MAc), emulated acupuncture (EAc), and electro-acupuncture (EA)-like peripheral electrical stimulation (PES). The discharges evoked by MAc and EAc were mostly in a burst pattern with average intra-burst and inter-burst firing rates of 90 Hz and 2 Hz, respectively. The frequency of discharges in PANs was correlated with the frequency of PES. The highest discharge frequency was 246 Hz in Aβ fibers and 180 Hz in Aδ fibers. Therefore, EA in a dense-disperse mode (at alternating frequency between 2 Hz and 15 Hz or between 2 Hz and 100 Hz) best mimics MAc. Frequencies of EA output >250 Hz appear to be obsolete for pain relief.

Indexed as

Acupuncture TherapyAfferent PathwaysElectric StimulationAnimalsAxonsRatsRats, Sprague-DawleyAcupunctureDorsal rootElectrophysiologyPeripheral electrical stimulationPrimary afferent fiberSingle unit recording

Identifiers

PMID32394277
PMCPMC7410905

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.