SynthesisNeuropsychology review2020
Behavioral and Psychological Symptoms that Predict Cognitive Decline or Impairment in Cognitively Normal Middle-Aged or Older Adults: a Meta-Analysis.
Synthesis in Neuropsychology review, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
27 citing papers in PubMed, 2 syntheses or guidelines pooled it, 42 citations in OpenAlex.
- Cognitive changes in people with diabetes with lower extremity complications compared to people with diabetes without lower extremity complications: a systematic review and meta-analysis.BMC endocrine disorders · 2024Pooled it
- Addressing depression in older adults with Alzheimer's through cognitive behavioral therapy: systematic review and meta-analysis.Frontiers in aging neuroscience · 2023Pooled it
- Feasibility of identifying factors related to Alzheimer's disease and related dementia in real-world data.JAMIA open · 2026Review
- Cognitive Impairment in People With Diabetes-Related Foot Ulcers: A Multicentre, Case-Control, Observational Study.International wound journal · 2026Observational
- Sleep duration, depressive symptoms, and postoperative delirium: a mediation analysis.Frontiers in psychiatry · 2026Article
- Characterization of subclinical depressive and anxiety symptoms in older adults with subjective cognitive decline progressing to objective cognitive impairment: A prospective 4-year follow-up study.Journal of Alzheimer's disease : JAD · 2025Article
- Role of NLRP3 Inflammasome in Chronic Pain and Alzheimer's Disease-A Review.Journal of biochemical and molecular toxicology · 2025Review
- Physiological, Psychological, and Functional Health Determinants of Depressive Symptoms Among the Elderly in India: Evaluation of Classification Performance of XGBoost Models.Indian journal of psychological medicine · 2025Article
- A study on the impact of chronic diseases and depressive symptoms comorbidity on the risk of cognitive impairment in middle-aged and older adults people based on the CHARLS database.Frontiers in public health · 2025Article
- Subjective Cognitive Impairment and Physical Activity: Investigating Risk Factors and Correlations among Older Adults in Spain.Journal of functional morphology and kinesiology · 2024Article
- Progress on early diagnosing Alzheimer's disease.Frontiers of medicine · 2024Review
- From macro to micro: slow-wave sleep and its pivotal health implications.Frontiers in sleep · 2024Review
- Sleep Quality and Cognitive Abilities in the Greek Cohort of Epirus Health Study.Nature and science of sleep · 2024Article
- AI-assisted neurocognitive assessment protocol for older adults with psychiatric disorders.Frontiers in psychiatry · 2024Article
- TBX21, the Master regulator of the type 1 immune response, overexpresses in the leukocytes of peripheral blood in patients with late-onset Alzheimer's disease.Immunity & ageing : I & A · 2023Article
- Sleep and Depression in Older Adults: A Narrative Review.Current psychiatry reports · 2023Review
- The role of sex differences in depression in pathologically defined Alzheimer's disease.Frontiers in aging neuroscience · 2023Article
- Cognitive Function among World Trade Center-Exposed Community Members with Mental Health Symptoms.International journal of environmental research and public health · 2022Article
- Clinical Perception and Treatment Options for Behavioral and Psychological Symptoms of Dementia (BPSD) in Italy.Frontiers in psychiatry · 2022Article
- Emotional characteristics of socially isolated older adults with MCI using tablet administered NIH toolbox: I-CONECT study.Alzheimer's & dementia (Amsterdam, Netherlands) · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
13 authors at 5 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Epidemiological studies have revealed that behavioral and psychological (or non-cognitive) symptoms are risk factors for cognitive decline in older adults. This study aimed to systematically review the literature and determine which behavioral and psychological symptoms are most predictive of future cognitive decline among individuals with no pre-existing cognitive impairments. The selected studies included middle-aged or older adults without cognitive impairments. The predictors were assessed using behavioral and psychological questionnaires, or diagnostic interviews, to identify non-cognitive symptoms or psychiatric clinical conditions. The follow-up period was at least one year, and the design of the selected studies was either retrospective or prospective. This study compared individuals with and without non-cognitive manifestations and resulted in one of three outcomes: (a) a score change on a cognitive measure, (b) a diagnosis of mild cognitive impairment, or (c) a diagnosis of Alzheimer's disease or dementia. Four online databases were searched for eligible studies from the database inception to January 17, 2017: MEDLINE (PubMed), Embase (OVID), PsycINFO, and Web of Science. Pooled effect sizes were estimated using a random-effect model. Higgins I
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.