ReviewEndocrine reviews2020
Muscle-Organ Crosstalk: The Emerging Roles of Myokines.
Review in Endocrine reviews, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. It is linked to 2 registered trials, which are not on this map. Cited by 686 papers, 7 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Characterizing Acute Exercise Response in Restrictive Eating Disorders
Effect of Supplementation With Euterpe Edulis on the Physical and Mental Performance of Healthy Men Subjecting to Physical Exercise
Who cites it
686 citing papers in PubMed, 7 syntheses or guidelines pooled it, 1,014 citations in OpenAlex.
- A systematic review of physical activity-based interventions to prevent or reduce chronic post-surgical pain.Pain medicine (Malden, Mass.) · 2026Pooled it
- Association Between Fat-Free Mass and Mortality: A Systematic Review and Meta-Analysis.Journal of cachexia, sarcopenia and muscle · 2026Pooled it
- Identification of potential diagnostic and therapeutic apoptosis-related casual targets for osteoporosis: an integrated multi-omics analysis.Journal of bone and mineral metabolism · 2026Pooled it
- Comparative efficacy of exercise modes on inflammatory cytokines in patients with breast cancer: a systematic review with pairwise and network meta-analyses.Scientific reports · 2026Pooled it
- Pooled it
- Comparative efficacy of exercise modalities added to energy restriction on inflammatory markers in obesity: a systematic review and network meta-analysis.Frontiers in nutrition · 2026Pooled it
- Exercise-induced changes in systemic inflammatory biomarkers in overweight and obese populations: a bibliometric analysis and umbrella review of meta-analyses.Frontiers in immunology · 2026Pooled it
- Bypassing the systemic cardiorespiratory threshold: neuromuscular electrical stimulation elicits a SPARC response through accelerated glycolytic flux.European journal of applied physiology · 2026Trial
- Within-Day Timing of Concurrent Training Affects Inflammation and Body Composition in Young Adults With Obesity.Obesity (Silver Spring, Md.) · 2026Trial
- Electroacupuncture Treatment on Sarcopenia in Patients Undergoing Maintenance Haemodialysis: An Effective Therapy.Journal of cachexia, sarcopenia and muscle · 2026Trial
- Home-based high-intensity exercise training during neoadjuvant chemotherapy is associated with favorable chemotherapy outcomes and tumor microenvironment remodeling in breast cancer.Cell communication and signaling : CCS · 2026Trial
- The impact of online-delivered controlled physical activity on cardiorespiratory fitness and heart rate variability in breast cancer survivors.Scientific reports · 2026Trial
- Trial
- Cardiac rehabilitation influences serum myokine levels in patients after acute coronary syndrome: the randomised CARDIO-REH study.Scientific reports · 2025Trial
- The interplay between vitamin D status and exerkine signaling: implications for exercise adaptation in athletes: narrative review.Journal of the International Society of Sports Nutrition · 2026Review
- Combined handgrip strength and incident chronic digestive diseases: a prospective parallel analysis examining broad and specific endpoints in Chinese and European older adults.Global health action · 2026Article
- Acute and lifelong exercise modulate the tumorigenic potential of human lung cancer cells and their susceptibility to cisplatin.Experimental physiology · 2026Article
- Acute exercise-induced lipolysis and increase in levels of fatty acid esters of hydroxy fatty acids in adipose tissue are impaired in obese and aged mice.Experimental physiology · 2026Article
- Changes in Muscle Mass and the Risk of Liver-Related Events: A Prospective Cohort Study.Diabetes, obesity & metabolism · 2026Article
- Effects of six weeks of hypoxia and hypoxic SIT on oxidative stress and myokine responses in skeletal muscle of high-fat-fed ApoEEuropean journal of applied physiology · 2026Article
626 more citing papers are in PubMed but not listed here.
Corrections and comments
- Erratum issued
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Physical activity decreases the risk of a network of diseases, and exercise may be prescribed as medicine for lifestyle-related disorders such as type 2 diabetes, dementia, cardiovascular diseases, and cancer. During the past couple of decades, it has been apparent that skeletal muscle works as an endocrine organ, which can produce and secrete hundreds of myokines that exert their effects in either autocrine, paracrine, or endocrine manners. Recent advances show that skeletal muscle produces myokines in response to exercise, which allow for crosstalk between the muscle and other organs, including brain, adipose tissue, bone, liver, gut, pancreas, vascular bed, and skin, as well as communication within the muscle itself. Although only few myokines have been allocated to a specific function in humans, it has been identified that the biological roles of myokines include effects on, for example, cognition, lipid and glucose metabolism, browning of white fat, bone formation, endothelial cell function, hypertrophy, skin structure, and tumor growth. This suggests that myokines may be useful biomarkers for monitoring exercise prescription for people with, for example, cancer, diabetes, or neurodegenerative diseases.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.