ArticleNature neuroscience2020
The claustrum coordinates cortical slow-wave activity.
Article in Nature neuroscience, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 115 papers, 1 of them a synthesis that pooled it.
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Who cites it
115 citing papers in PubMed, 1 synthesis or guideline pooled it, 224 citations in OpenAlex.
- Human lesions and animal studies link the claustrum to perception, salience, sleep and pain.Brain : a journal of neurology · 2022Pooled it
- Paroxysmal slow waves mark ictal networks.Epilepsia · 2026Article
- A claustro-cortical loop times state transitions for flexible behavior.Research square · 2026Article
- New functional insights from the monkey claustrum.National science review · 2026Review
- A claustro-cortical loop times state transitions for flexible behavior.bioRxiv : the preprint server for biology · 2026Article
- The primate claustrum as a hub for precision weighting of prediction errors across the cortical hierarchy.PLoS biology · 2026Article
- The Human Visual Claustrum Responses to Physical Stimulus Properties and Subjective Content During Movie Viewing.Human brain mapping · 2026Article
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- Homeostatic coupling of cortical and brainstem delta rhythms in sleeping infant rats.bioRxiv : the preprint server for biology · 2026Article
- Wavelength-dependent sleep state manipulation using light pulses in Pogona vitticeps.Communications biology · 2026Article
- Cell-type-specific sustained value representations in the claustrum.bioRxiv : the preprint server for biology · 2026Article
- Nurr1 Orchestrates Claustrum Development and Functionality.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- The effect of psilocin on neurotransmitters release in the claustrum and on rat behavior.Pharmacological reports : PR · 2026Article
- Similarities of neocortical deep layeriScience · 2025Article
- The claustrum enhances neural variability by modulating the responsiveness of the prefrontal cortex.Nature communications · 2025Article
- Convergent Control of NREM Sleep and Anesthesia by Prefrontal Layer 5 Extratelencephalic Neurons.Research square · 2025Article
- Topographic organisation of the claustrum-amygdala-prefrontal circuitry in the common marmoset (Callithrix jacchus).Brain structure & function · 2025Article
- Global and local nature of cortical slow waves.iScience · 2025Article
- Serotonin and psilocybin activate 5-HTNature communications · 2025Article
55 more citing papers are in PubMed but not listed here.
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8 authors at 2 institutions in 2 countries.
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No grant is acknowledged in the PubMed record.
Abstract
During sleep and awake rest, the neocortex generates large-scale slow-wave (SW) activity. Here, we report that the claustrum coordinates neocortical SW generation. We established a transgenic mouse line that enabled the genetic interrogation of a subpopulation of claustral glutamatergic neurons. These neurons received inputs from and sent outputs to widespread neocortical areas. The claustral neuronal firings mostly correlated with cortical SW activity. In vitro optogenetic stimulation of the claustrum induced excitatory postsynaptic responses in most neocortical neurons, but elicited action potentials primarily in inhibitory interneurons. In vivo optogenetic stimulation induced a synchronized down-state featuring prolonged silencing of neural activity in all layers of many cortical areas, followed by a down-to-up state transition. In contrast, genetic ablation of claustral neurons attenuated SW activity in the frontal cortex. These results demonstrate a crucial role of claustral neurons in synchronizing inhibitory interneurons across wide cortical areas for the spatiotemporal coordination of SW activity.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.