Evidence map›Paper›PMID 32393857›Full record

ArticleNature microbiology2020

Structural and functional insights into oligopeptide acquisition by the RagAB transporter from Porphyromonas gingivalis.

Mariusz Madej, Joshua B R White, Zuzanna Nowakowska, Shaun Rawson, Carsten Scavenius, Jan J Enghild, Grzegorz P Bereta, Karunakar Pothula, Ulrich Kleinekathoefer, Arnaud Baslé and 3 more

Open access · bronzeAbstract read
In one paragraph

Article in Nature microbiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers.

0numbers the graph read from it
0cells of the map it votes in
44citing papers in PubMed
4.4field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

44 citing papers in PubMed, 74 citations in OpenAlex.

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  14. Exploring the Genetic and Functional Diversity ofInternational journal of molecular sciences · 2025
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  15. TheFrontiers in cellular and infection microbiology · 2025
    Article
  16. Review
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  18. Prevalence and Phylogenetic Analysis of Lipoprotein-GeneAntibiotics (Basel, Switzerland) · 2023
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 5 institutions in 5 countries.

Mariusz Madej *Department of Microbiology, Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University, Krakow, Poland.ORCID http://orcid.org/0000-0002-9935-3871
Joshua B R White *Astbury Centre for Structural Molecular Biology, Faculty of Biological Sciences, University of Leeds, Leeds, UK.ORCID http://orcid.org/0000-0003-4655-3121
Zuzanna NowakowskaDepartment of Microbiology, Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University, Krakow, Poland.ORCID http://orcid.org/0000-0003-2848-7538
Shaun RawsonAstbury Centre for Structural Molecular Biology, Faculty of Biological Sciences, University of Leeds, Leeds, UK.ORCID http://orcid.org/0000-0002-2973-2630
Carsten ScaveniusInterdisciplinary Nanoscience Center (iNANO) and the Department of Molecular Biology, Aarhus University, Aarhus, Denmark.
Jan J EnghildInterdisciplinary Nanoscience Center (iNANO) and the Department of Molecular Biology, Aarhus University, Aarhus, Denmark.
Grzegorz P BeretaDepartment of Microbiology, Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University, Krakow, Poland.ORCID http://orcid.org/0000-0002-2925-7796
Karunakar PothulaDepartment of Physics and Earth Sciences, Jacobs University Bremen, Bremen, Germany.
Ulrich KleinekathoeferDepartment of Physics and Earth Sciences, Jacobs University Bremen, Bremen, Germany.ORCID http://orcid.org/0000-0002-6114-7431
Arnaud BasléBiosciences Institute, The Medical School, Newcastle University, Newcastle upon Tyne, UK.
Neil A RansonAstbury Centre for Structural Molecular Biology, Faculty of Biological Sciences, University of Leeds, Leeds, UK. n.a.ranson@leeds.ac.uk.ORCID http://orcid.org/0000-0002-3640-5275
Jan PotempaDepartment of Microbiology, Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University, Krakow, Poland. jan.potempa@icloud.com.ORCID http://orcid.org/0000-0002-3600-7461
Bert van den BergBiosciences Institute, The Medical School, Newcastle University, Newcastle upon Tyne, UK. bert.van-den-berg@ncl.ac.uk.ORCID http://orcid.org/0000-0003-1966-8804
Jagiellonian University · PLUniversity of Leeds · GBAarhus University · DKConstructor University · DENewcastle University · GB

Funding

Bacterial peptidylarginine deiminase, a link between gums and joint diseaseR01DE022597 · NIDCR · UNIVERSITY OF LOUISVILLE · PI POTEMPA, JAN S · 2013 to 2023
$3.7M
NIDCR NIH HHS R01 DE022597Wellcome Trust 108466Wellcome Trust 108466/Z/15/ZWellcome Trust 214222Wellcome Trust 214222/Z/18/ZWellcome Trust 215064/Z/18/Z
6 · The paper itself

Abstract

Porphyromonas gingivalis, an asaccharolytic member of the Bacteroidetes, is a keystone pathogen in human periodontitis that may also contribute to the development of other chronic inflammatory diseases. P. gingivalis utilizes protease-generated peptides derived from extracellular proteins for growth, but how these peptides enter the cell is not clear. Here, we identify RagAB as the outer-membrane importer for these peptides. X-ray crystal structures show that the transporter forms a dimeric RagA

Indexed as

Bacterial ProteinsCryoelectron MicroscopyCrystallography, X-RayMembrane Transport ProteinsMolecular Dynamics SimulationOligopeptidesPeriodontitisPorphyromonas gingivalisProtein ConformationBacterial ProteinsMembrane Transport ProteinsOligopeptidesRagA protein, Porphyromonas gingivalisRagB protein, bacteria

Identifiers

PMID32393857
PMCPMC7610489
OpenAlexW3023628373

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.