Evidence map›Paper›PMID 32393826›Full record

ReviewNature reviews. Rheumatology2020

Restoring synovial homeostasis in rheumatoid arthritis by targeting fibroblast-like synoviocytes.

Gyrid Nygaard, Gary S Firestein

Open access · greenAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Nature reviews. Rheumatology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 496 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
496citing papers in PubMed, 3 pooled it
56.6field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

496 citing papers in PubMed, 3 syntheses or guidelines pooled it, 865 citations in OpenAlex.

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436 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 1 country.

Gyrid NygaardDivision of Rheumatology, Allergy and Immunology, University of California San Diego School of Medicine, San Diego, CA, USA.
Gary S FiresteinDivision of Rheumatology, Allergy and Immunology, University of California San Diego School of Medicine, San Diego, CA, USA. gfirestein@health.ucsd.edu.ORCID http://orcid.org/0000-0003-3495-960X
UC San Diego Health System · USUniversity of California San Diego · US

Funding

Identification of key regulators in rheumatoid arthritisR01AR065466 · NIAMS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI FIRESTEIN, GARY S, WANG, WEI · 2014 to 2024
$4.6M
Joint-location specific pathogenic pathways in rheumatoid arthritisR01AR071321 · NIAMS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI FIRESTEIN, GARY S, WANG, WEI · 2018 to 2023
$1.7M
NIAMS NIH HHS R01 AR065466NIAMS NIH HHS R01 AR071321
6 · The paper itself

Abstract

Rheumatoid arthritis (RA) is a chronic immune-mediated disease that primarily affects the synovium of diarthrodial joints. During the course of RA, the synovium transforms into a hyperplastic invasive tissue that causes destruction of cartilage and bone. Fibroblast-like synoviocytes (FLS), which form the lining of the joint, are epigenetically imprinted with an aggressive phenotype in RA and have an important role in these pathological processes. In addition to producing the extracellular matrix and joint lubricants, FLS in RA produce pathogenic mediators such as cytokines and proteases that contribute to disease pathogenesis and perpetuation. The development of multi-omics integrative analyses have enabled new ways to dissect the mechanisms that imprint FLS, have helped to identify potential FLS subsets with distinct functions and have identified differences in FLS phenotypes between joints in individual patients. This Review provides an overview of advances in understanding of FLS biology and highlights omics approaches and studies that hold promise for identifying future therapeutic targets.

Indexed as

Arthritis, RheumatoidB-LymphocytesBone ResorptionCadherinsCartilage, ArticularDNA MethylationEndothelial CellsEpigenesis, GeneticFibroblastsHumansMacrophagesMolecular Targeted TherapyMonocytesNeovascularization, PathologicOsteogenesisProtein Tyrosine PhosphatasesCadherinsosteoblast cadherinProtein Tyrosine Phosphatases

Identifiers

PMID32393826
PMCPMC7987137
OpenAlexW3022414345

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.