ArticleNature biotechnology2020
A male-biased sex-distorter gene drive for the human malaria vector Anopheles gambiae.
Article in Nature biotechnology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 118 papers.
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Who cites it
118 citing papers in PubMed.
- Mosquito-based malaria control through genetic, microbial and immunological innovations.Nature reviews. Microbiology · 2026Review
- Heterochromatin protein 1 (HP1) dysfunction drives male-biased sex ratio in Trichogramma dendrolimi (Hymenoptera: Trichogrammatidae) via paternal genome elimination during mitosis.Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology · 2026Article
- Engineering resilient gene drives for sustainable malaria control by predicting, testing and overcoming target site resistance in Anopheles gambiae.PLoS biology · 2026Article
- Self-limiting population suppression gene drive design in the West Nile vector mosquito, Culex quinquefasciatus.Nature communications · 2026Article
- Decoding cis-regulatory elements in the germline of the human malaria vector Anopheles gambiae.Communications biology · 2026Article
- Sex distorter male drive for resistance-resilient population control of the human malaria vector Anopheles gambiae.Nature communications · 2026Article
- Seed dormancy shapes gene drive dynamics in plants.Nature plants · 2026Article
- Exploratory conversations with biodiversity-oriented civil society groups on the potential applications of gene drive-modified mosquitoes for malaria control in Tanzania.Transgenic research · 2026Article
- A Culturally Grounded Method for Dialogue Between Indigenous Peoples and Researchers on Emerging Technologies: Lessons from the Gene Drive Context.Gates open research · 2026Article
- Age-dependent mating dynamics, body size, and sex ratio in colonisedCurrent research in parasitology & vector-borne diseases · 2026Article
- Advances in population-based interventions to control falciparum malaria.Transactions of the Royal Society of Tropical Medicine and Hygiene · 2025Review
- Outdoor biting by malaria vectors: what are the options for intervention?Malaria journal · 2025Review
- Predicting the invasiveness of threshold-dependent gene drives.bioRxiv : the preprint server for biology · 2025Article
- Single-cell consequences of X-linked meiotic drive in stalk-eyed flies.PLoS genetics · 2025Article
- CRISPR technologies for the control and study of malaria-transmitting anopheline mosquitoes.Parasites & vectors · 2025Review
- Multi-Omic Analysis Identifies Key Genes Driving Testicular Fusion inInternational journal of molecular sciences · 2025Article
- Understanding the genetics of sex determination in insects and its relevance to genetic pest management.Insect molecular biology · 2025Review
- A suppression-modification gene drive for malaria control targeting the ultra-conserved RNA gene mir-184.Nature communications · 2025Article
- ExploitingPathogens (Basel, Switzerland) · 2025Review
- A Comparative Assessment of Self-limiting Genetic Control Strategies for Population Suppression.Molecular biology and evolution · 2025Article
58 more citing papers are in PubMed but not listed here.
Corrections and comments
- Erratum issued
Authors and funding
12 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Only female insects transmit diseases such as malaria, dengue and Zika; therefore, control methods that bias the sex ratio of insect offspring have long been sought. Genetic elements such as sex-chromosome drives can distort sex ratios to produce unisex populations that eventually collapse, but the underlying molecular mechanisms are unknown. We report a male-biased sex-distorter gene drive (SDGD) in the human malaria vector Anopheles gambiae. We induced super-Mendelian inheritance of the X-chromosome-shredding I-PpoI nuclease by coupling this to a CRISPR-based gene drive inserted into a conserved sequence of the doublesex (dsx) gene. In modeling of invasion dynamics, SDGD was predicted to have a quicker impact on female mosquito populations than previously developed gene drives targeting female fertility. The SDGD at the dsx locus led to a male-only population from a 2.5% starting allelic frequency in 10-14 generations, with population collapse and no selection for resistance. Our results support the use of SDGD for malaria vector control.
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