ArticleNature medicine2020
T cell-inducing vaccine durably prevents mucosal SHIV infection even with lower neutralizing antibody titers.
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Article in Nature medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 122 papers.
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0cells of the map it votes in
122citing papers in PubMed
16.6field-weighted citation impact, top 1% of its field
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
122 citing papers in PubMed, 167 citations in OpenAlex.
- Focusing HIV-1 Gag T cell responses to highly conserved regions by DNA vaccination in HVTN 119.JCI insight · 2024Trial
- Trivalent mosaic or consensus HIV immunogens prime humoral and broader cellular immune responses in adults.The Journal of clinical investigation · 2023Trial
- A scientific journey through viral immunology, vaccines, and neuroinflammation.Human vaccines & immunotherapeutics · 2026Article
- Rapid and robust immune response boosting with potent, next-generation adjuvant in viral vector-primed primates.Journal of virology · 2026Article
- The SATvac model of CD8+ T cell expansion and contraction phases considering memory and effector cell differentiation.PLoS computational biology · 2026Article
- Review
- HLA-E-restricted T cells primed by a modified HLA-B*57:01-restricted HIV-1 peptide suppress HIV-1 replication.JCI insight · 2026Article
- Non-human primate LIBRA-Seq accelerates neutralizing antibody discovery in RM vaccinated against HIV-1.PLoS pathogens · 2026Article
- Review
- T-Cell Biology in the Female Reproductive Tract: Relevance to HIV Infection.American journal of reproductive immunology (New York, N.Y. : 1989) · 2026Review
- HIV-1 BG505 SOSIP immunization induced B cell expansion targeting the 465-glycan hole, with neutralizing antibodies exhibiting distinct binding modes and mechanisms of virus inhibition.PLoS pathogens · 2026Article
- Population-level genomic analysis of immunoglobulin loci variation in rhesus macaques reveals extensive germline diversity.Immunity · 2026Article
- Funding Strategies to Foster Enabling Basic Science Research in the Development of an HIV Vaccine.Current HIV research · 2026Review
- Accelerating Innovation: Advancing Opportunities in HIV Vaccine Development.Current HIV research · 2026Review
- Current Approaches for Assessments of Neutralizing, Binding, and Effector Functions of Antibodies on the Path to Antibody-Mediated Prevention Strategies for HIV-1.Current HIV research · 2026Review
- Lipid nanoparticle-based mRNA platforms for mucosal HIV vaccines: formulation advances, immune mechanisms, and translational pathways.Archives of microbiology · 2025Review
- Tanshinone I Enhances the Pulmonary Immune Response of CD8Biomedicines · 2025Article
- Article
- Vaccination with an mRNA-encoded membrane-bound HIV envelope trimer induces neutralizing antibodies in animal models.Science translational medicine · 2025Article
- Review
62 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
34 authors at 17 institutions in 3 countries.
Prabhu S Arunachalam *Institute for Immunity, Transplantation and Infection, Stanford University School of Medicine, Stanford University, Stanford, CA, USA.
Tysheena P Charles *Department of Pathology and Laboratory Medicine, Emory Vaccine Center, Yerkes National Primate Research Center, Atlanta, GA, USA.
Vineet Joag *Department of Microbiology and Immunology, Center for Immunology, University of Minnesota, Minneapolis, MN, USA.ORCID http://orcid.org/0000-0002-0723-3347
Venkata S Bollimpelli *Department of Microbiology and Immunology, Emory Vaccine Center, Yerkes National Primate Research Center at Emory University, Atlanta, GA, USA.
Madeleine K D ScottInstitute for Immunity, Transplantation and Infection, Stanford University School of Medicine, Stanford University, Stanford, CA, USA.
Florian WimmersInstitute for Immunity, Transplantation and Infection, Stanford University School of Medicine, Stanford University, Stanford, CA, USA.
Samantha L BurtonDepartment of Pathology and Laboratory Medicine, Emory Vaccine Center, Yerkes National Primate Research Center, Atlanta, GA, USA.
Celia C LabrancheDepartment of Surgery, Duke University School of Medicine, Durham, NC, USA.
Caroline PetitdemangeDepartment of Microbiology and Immunology, Emory Vaccine Center, Yerkes National Primate Research Center at Emory University, Atlanta, GA, USA.
Sailaja GangadharaDepartment of Microbiology and Immunology, Emory Vaccine Center, Yerkes National Primate Research Center at Emory University, Atlanta, GA, USA.ORCID http://orcid.org/0000-0001-8603-628X
Tiffany M StylesDepartment of Microbiology and Immunology, Emory Vaccine Center, Yerkes National Primate Research Center at Emory University, Atlanta, GA, USA.
Clare F QuarnstromDepartment of Microbiology and Immunology, Center for Immunology, University of Minnesota, Minneapolis, MN, USA.
Korey A WalterDepartment of Microbiology, Immunology, and Parasitology, Louisiana State University Health Sciences Center, New Orleans, LA, USA.
Thomas J KetasDepartment of Microbiology and Immunology, Weill Medical College of Cornell University, New York, NY, USA.
Traci LegereDepartment of Microbiology and Immunology, Emory Vaccine Center, Yerkes National Primate Research Center at Emory University, Atlanta, GA, USA.
Pradeep Babu Jagadeesh ReddyDepartment of Microbiology and Immunology, Emory Vaccine Center, Yerkes National Primate Research Center at Emory University, Atlanta, GA, USA.
Sudhir Pai KasturiDepartment of Pathology and Laboratory Medicine, Emory Vaccine Center, Yerkes National Primate Research Center, Atlanta, GA, USA.
Anthony TsaiBioLegend, San Diego, CA, USA.
Bertrand Z YeungBioLegend, San Diego, CA, USA.
Shakti GuptaDepartment of Bioengineering, University of California, San Diego, La Jolla, CA, USA.
Mark Tomai3M Corporate Research and Materials Lab, Saint Paul, MN, USA.
John Vasilakos3M Drug Delivery Systems, Saint Paul, MN, USA.
George M ShawDepartment of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Chil-Yong KangDepartment of Microbiology and Immunology, Schulich School of Medicine & Dentistry, The University of Western Ontario, London, Ontario, Canada.
John P MooreDepartment of Microbiology and Immunology, Weill Medical College of Cornell University, New York, NY, USA.ORCID http://orcid.org/0000-0002-9902-6096
Shankar SubramaniamDepartment of Bioengineering, University of California, San Diego, La Jolla, CA, USA.
Purvesh KhatriInstitute for Immunity, Transplantation and Infection, Stanford University School of Medicine, Stanford University, Stanford, CA, USA.
David MontefioriDepartment of Surgery, Duke University School of Medicine, Durham, NC, USA.
Pamela A KozlowskiDepartment of Microbiology, Immunology, and Parasitology, Louisiana State University Health Sciences Center, New Orleans, LA, USA.
Cynthia A DerdeynDepartment of Pathology and Laboratory Medicine, Emory Vaccine Center, Yerkes National Primate Research Center, Atlanta, GA, USA. cderdey@emory.edu.ORCID http://orcid.org/0000-0002-1220-513X
Eric HunterDepartment of Pathology and Laboratory Medicine, Emory Vaccine Center, Yerkes National Primate Research Center, Atlanta, GA, USA. ehunte4@emory.edu.ORCID http://orcid.org/0000-0002-4273-8631
David MasopustDepartment of Microbiology and Immunology, Center for Immunology, University of Minnesota, Minneapolis, MN, USA. masopust@umn.edu.ORCID http://orcid.org/0000-0002-9440-3884
Rama R AmaraDepartment of Microbiology and Immunology, Emory Vaccine Center, Yerkes National Primate Research Center at Emory University, Atlanta, GA, USA. ramara@emory.edu.ORCID http://orcid.org/0000-0002-6309-6797
Bali PulendranInstitute for Immunity, Transplantation and Infection, Stanford University School of Medicine, Stanford University, Stanford, CA, USA. bpulend@stanford.edu.ORCID http://orcid.org/0000-0001-6517-4333
Emory University · USStanford University · USBioLegend (United States) · USCornell University · USDuke University · USEmory National Primate Research CenterLouisiana State University Health Sciences Center New Orleans · USUniversity of California San Diego · USUniversity of Minnesota Medical Center · US3M (United States) · USAtlanta VA Medical Center · USEmory and Henry College · USEmory Healthcare · USKindeva Drug Delivery (United States) · USUniversity of Minnesota · USUniversity of Pennsylvania · USWestern University · CA
Funding
Yerkes National Primate Research Center Role of type-I IFN in regulating COVID-19 induced inflammation and pathogenesisP51OD011132 · OD · EMORY UNIVERSITY · PI Joon Sup Lee · 2012 to 2026
$167.0MZETA CHAIN OF T CELL RECEPTOR INTERACTS W/ NEF OF SIV &HIV2P51RR000168 · NCRR · HARVARD UNIVERSITY (MEDICAL SCHOOL) · PI ROWLETT, JAMES K · 1985 to 2011
$139.3MSupport Component D/Vaccine Discovery, Concept to ClinicUM1AI100663 · NIAID · SCRIPPS RESEARCH INSTITUTE, THE · PI BAROUCH, DAN H. · 2012 to 2018
$131.5MVirology and Molecular Biomarkers CoreP30AI050409 · NIAID · EMORY UNIVERSITY · PI Ann M Chahroudi, Colleen F Kelley · 2002 to 2026
$74.0MSystems Biological Analysis of Innate and Adaptive Responses to VaccinationU19AI090023 · NIAID · EMORY UNIVERSITY · PI AHMED, RAFI, LI, SHUZHAO · 2010 to 2021
$45.0MB and T Cell Biology of Protection from and Eradication of SIV/SHIV Infection - Administrative SupplementUM1AI124436 · NIAID · EMORY UNIVERSITY · PI AMARA, RAMA RAO, HUNTER, ERIC · 2016 to 2021
$42.3MVirus and Antibody Gene Sequencing CoreP01AI131251 · NIAID · UNIVERSITY OF PENNSYLVANIA · PI Kevin Wiehe · 2017 to 2026
$40.7MStructural studies of native-like SOSIP trimersP01AI110657 · NIAID · WEILL MEDICAL COLL OF CORNELL UNIV · PI MOORE, JOHN P · 2015 to 2024
$35.4MMICROBES, DENDRITIC CELL SUBSETS AND T-CELL IMMUNITYR01AI048638 · NIAID · STANFORD UNIVERSITY · PI PULENDRAN, BALI · 2001 to 2024
$4.5MTargeting 5' leader-encoded defective ribosomal products for HIV T cell vaccinesR01AI118549 · NIAID · UNIVERSITY OF PENNSYLVANIA · PI SHAW, GEORGE M · 2016 to 2020
$3.6MEmory R38 Research Training ProgramR38AI140299 · NIAID · EMORY UNIVERSITY · PI OFOTOKUN, IGHOVWERHA, ROUPHAEL, NADINE GEORGES · 2018 to 2021
$1.4MNCRR NIH HHS P51 RR000168NIAID NIH HHS P01 AI110657NIAID NIH HHS P01 AI131251NIAID NIH HHS P30 AI050409NIAID NIH HHS R01 AI048638NIAID NIH HHS R01 AI118549NIAID NIH HHS R38 AI140299NIAID NIH HHS U19 AI090023NIAID NIH HHS UM1 AI100663NIAID NIH HHS UM1 AI124436NIH HHS P51 OD011132
Abstract
Recent efforts toward an HIV vaccine focus on inducing broadly neutralizing antibodies, but eliciting both neutralizing antibodies (nAbs) and cellular responses may be superior. Here, we immunized macaques with an HIV envelope trimer, either alone to induce nAbs, or together with a heterologous viral vector regimen to elicit nAbs and cellular immunity, including CD8
Indexed as
AnimalsAntibodies, NeutralizingAntibodies, ViralCD4-Positive T-LymphocytesCD8-Positive T-LymphocytesFemaleGene Products, gagGenetic VectorsImmunity, CellularImmunity, HeterologousImmunogenicity, VaccineImmunologic MemoryMacaca mulattaMucous MembraneSAIDS VaccinesSimian Acquired Immunodeficiency SyndromeAntibodies, NeutralizingAntibodies, ViralGene Products, gagSAIDS Vaccines
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.