Evidence map›Paper›PMID 32393798›Full record

ArticleActa pharmacologica Sinica2021

An optically active isochroman-2H-chromene conjugate potently suppresses neuronal oxidative injuries associated with the PI3K/Akt and MAPK signaling pathways.

Ling-Xue Tao, Sha-Sha Ji, Dóra Szalóki, Tibor Kovács, Attila Mándi, Sándor Antus, Xun Ding, Tibor Kurtán, Hai-Yan Zhang

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Acta pharmacologica Sinica, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.3field-weighted citation impact, top 47% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 11 citations in OpenAlex.

  1. Review
  2. Stereoselective Synthesis of Axially Chiral 5,5'-LinkedInternational journal of molecular sciences · 2025
    Article
  3. Article
  4. Article
  5. [1,5]-Hydride Shift-CyclizationMolecules (Basel, Switzerland) · 2020
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 2 countries.

Ling-Xue Tao *CAS Key Laboratory of Receptor Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 201203, China.
Sha-Sha Ji *CAS Key Laboratory of Receptor Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 201203, China.
Dóra SzalókiDepartment of Organic Chemistry, University of Debrecen, Debrecen, P. O. Box 400, H-4002, Debrecen, Hungary.
Tibor KovácsDepartment of Organic Chemistry, University of Debrecen, Debrecen, P. O. Box 400, H-4002, Debrecen, Hungary.
Attila MándiDepartment of Organic Chemistry, University of Debrecen, Debrecen, P. O. Box 400, H-4002, Debrecen, Hungary.
Sándor AntusDepartment of Organic Chemistry, University of Debrecen, Debrecen, P. O. Box 400, H-4002, Debrecen, Hungary.
Xun DingCAS Key Laboratory of Receptor Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 201203, China.
Tibor KurtánDepartment of Organic Chemistry, University of Debrecen, Debrecen, P. O. Box 400, H-4002, Debrecen, Hungary. kurtan.tibor@science.unideb.hu.
Hai-Yan ZhangCAS Key Laboratory of Receptor Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 201203, China. hzhang@simm.ac.cn.
University of Debrecen · HUChinese Academy of Sciences · CNShanghai Institute of Materia Medica · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Increasing evidence suggests that the use of potent neuroprotective agents featured with novel pharmacological mechanism would offer a promising strategy to delay or prevent the progression of neurodegeneration. Here, we provide the first demonstration that the chiral nonracemic isochroman-2H-chromene conjugate JE-133, a novel synthetic 1,3-disubstituted isochroman derivative, possesses superior neuroprotective effect against oxidative injuries. Pretreatment with JE-133 (1-10 μM) concentration-dependently prevented H

Indexed as

AnimalsApoptosisBenzopyransCell Line, TumorFree Radical ScavengersHumansHydrogen PeroxideMAP Kinase Signaling SystemNeuronsNeuroprotectionNeuroprotective AgentsOxidative StressPhosphatidylinositol 3-KinasesProto-Oncogene Proteins c-aktRatsRats, Sprague-DawleyBenzopyransFree Radical ScavengersHydrogen PeroxideNeuroprotective AgentsPhosphatidylinositol 3-KinasesProto-Oncogene Proteins c-aktapoptosisMAPK pathwayneurodegenerationoxidative stressPI3K/Akt pathwaySH-SY5Y neuroblastoma cells

Identifiers

PMID32393798
PMCPMC7921582
OpenAlexW3023497689

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.