Evidence map›Paper›PMID 32393638›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2020

Evolutionarily ancient BAH-PHD protein mediates Polycomb silencing.

Elizabeth T Wiles, Kevin J McNaught, Gurmeet Kaur, Jeanne M L Selker, Tereza Ormsby, L Aravind, Eric U Selker

Open access · greenAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.

0numbers the graph read from it
0cells of the map it votes in
32citing papers in PubMed
6.7field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

32 citing papers in PubMed, 40 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Article
  6. HISTONE DEACETYLASE-1 is required for epigenome stability inProceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  7. Article
  8. The RPD3L deacetylation complex is required for facultative heterochromatin repression inProceedings of the National Academy of Sciences of the United States of America · 2024
    Article
  9. Review
  10. Article
  11. Review
  12. Article
  13. Article
  14. Review
  15. Article
  16. Article
  17. Polycomb Repressive Complex 2 in Oncology.Cancer treatment and research · 2023
    Article
  18. Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Elizabeth T WilesInstitute of Molecular Biology, University of Oregon, Eugene, OR 97403.ORCID 0000-0001-7269-7466
Kevin J McNaughtInstitute of Molecular Biology, University of Oregon, Eugene, OR 97403.ORCID 0000-0002-6887-3161
Gurmeet KaurNational Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, MD 20894.ORCID 0000-0003-2442-1515
Jeanne M L SelkerInstitute of Molecular Biology, University of Oregon, Eugene, OR 97403.ORCID 0000-0002-0562-8935
Tereza OrmsbyInstitute of Molecular Biology, University of Oregon, Eugene, OR 97403.ORCID 0000-0002-2953-9208
L AravindNational Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, MD 20894.ORCID 0000-0003-0771-253X
Eric U SelkerInstitute of Molecular Biology, University of Oregon, Eugene, OR 97403; selker@uoregon.edu.ORCID 0000-0001-6465-0094
University of Oregon · USNational Institutes of Health · US

Funding

DEVELOPMENTAL BIOLOGY TRAINING PROGRAMT32HD007348 · NICHD · UNIVERSITY OF OREGON · PI Chris Q Doe, KRYN STANKUNAS · 1989 to 2026
$6.8M
Control and function of heterochromatin in Neurospora crassaR35GM127142 · NIGMS · UNIVERSITY OF OREGON · PI SELKER, ERIC U. · 2018 to 2022
$2.6M
Control and Function of Histone H3 Lysine 27 Methylation in NeurosporaR01GM093061 · NIGMS · UNIVERSITY OF OREGON · PI SELKER, ERIC U. · 2012 to 2015
$1.1M
NICHD NIH HHS T32 HD007348NIGMS NIH HHS R01 GM093061NIGMS NIH HHS R35 GM127142
6 · The paper itself

Abstract

Methylation of histone H3 lysine 27 (H3K27) is widely recognized as a transcriptionally repressive chromatin modification but the mechanism of repression remains unclear. We devised and implemented a forward genetic scheme to identify factors required for H3K27 methylation-mediated silencing in the filamentous fungus

Indexed as

Evolution, MolecularGene SilencingHomeodomain ProteinsPolycomb-Group ProteinsEpigenesis, GeneticFungal ProteinsHeterochromatinHistone CodeMethylationNeurospora crassaPlant ProteinsFungal ProteinsHeterochromatinHomeodomain ProteinsPlant ProteinsPolycomb-Group Proteinsepigeneticsfacultative heterochromatinH3K27 methylationhistone readerPolycomb repressive complex

Identifiers

PMID32393638
PMCPMC7261115
OpenAlexW3021201604

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.