ArticleProceedings of the National Academy of Sciences of the United States of America2020
Evaluation of plant sources for antiinfective lead compound discovery by correlating phylogenetic, spatial, and bioactivity data.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
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Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Ethnomedicinal landscape: distribution of used medicinal plant species in Nepal.Journal of ethnobiology and ethnomedicine · 2022Pooled it
- Combined phylogenetic and geographic data can predict plant-pest interactions with high accuracy.The New phytologist · 2026Article
- NPASS database update 2026: comprehensive quantitative composition, bioactivity, and ADME-Tox data of natural products for biomedical research.Nucleic acids research · 2026Article
- Association between bat-predator species richness and Nipah virus spillover risk in Bangladesh.One health (Amsterdam, Netherlands) · 2025Article
- The Role of Nucleotide Sequencing in Natural Product Drug Discovery.Journal of natural products · 2025Review
- Phylogeny, ethnomedicinal use and the distribution of phytoestrogens in the Fabaceae.Frontiers in pharmacology · 2025Article
- Phytochemicals in Drug Discovery-A Confluence of Tradition and Innovation.International journal of molecular sciences · 2024Review
- Leveraging off higher plant phylogenetic insights for antiplasmodial drug discovery.Natural products and bioprospecting · 2023Article
- How to approach a study in ethnopharmacology? Providing an example of the different research stages for newcomers to the field today.Pharmacology research & perspectives · 2023Review
- Lead Drug Discover Strategies from Natural Medicines Based on Network Pharmacology.Medical research archives · 2023Article
- Machine learning enhances prediction of plants as potential sources of antimalarials.Frontiers in plant science · 2023Article
- Genome sequence and population genomics provide insights into chromosomal evolution and phytochemical innovation of Hippophae rhamnoides.Plant biotechnology journal · 2022Article
- Prof. Ludger Wessjohann: A Lifelong Career Dedicated to a Remarkable Service in "Natural Products Sciences".International journal of molecular sciences · 2022Article
- Editorial: Developing therapeutics for antimicrobial resistant pathogens.Frontiers in cellular and infection microbiology · 2022Article
- Computational Applications in Secondary Metabolite Discovery (CAiSMD): an online workshop.Journal of cheminformatics · 2021Article
- Review
- Spatial and evolutionary predictability of phytochemical diversity.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Antibiotic resistance and viral diseases are rising around the world and are becoming major threats to global health, food security, and development. One measure that has been suggested to mitigate this crisis is the development of new antibiotics. Here, we provide a comprehensive evaluation of the phylogenetic and biogeographic patterns of antiinfective compounds from seed plants in one of the most species-rich regions on Earth and identify clades with naturally occurring substances potentially suitable for the development of new pharmaceutical compounds. Specifically, we combine taxonomic and phylogenetic data for >7,500 seed plant species from the flora of Java with >16,500 secondary metabolites and 6,255 georeferenced occurrence records to 1) identify clades in the phylogeny that are characterized by either an overrepresentation ("hot clades") or an underrepresentation ("cold clades") of antiinfective compounds and 2) assess the spatial patterns of plants with antiinfective compounds relative to total plant diversity across the region. Across the flora of Java, we identify 26 "hot clades" with plant species providing a high probability of finding antibiotic constituents. In addition, 24 "cold clades" constitute lineages with low numbers of reported activities but which have the potential to yield novel compounds. Spatial patterns of plant species and metabolite diversity are strongly correlated across Java, indicating that regions of highest species diversity afford the highest potential to discover novel natural products. Our results indicate that the combination of phylogenetic, spatial, and phytochemical information is a useful tool to guide the selection of taxa for efforts aimed at lead compound discovery.
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