Evidence map›Paper›PMID 32393585›Full record

ArticleeNeuro

Role of Synaptic Inhibition in the Coupling of the Respiratory Rhythms that Underlie Eupnea and Sigh Behaviors.

Daniel S Borrus, Cameron J Grover, Gregory D Conradi Smith, Christopher A Del Negro

Abstract read
In one paragraph

Article in eNeuro. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Review
  6. Article
  7. The sigh and related behaviors.Handbook of clinical neurology · 2022
    Review
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Daniel S BorrusDepartment of Applied Science, Integrated Science Center, William & Mary, Williamsburg, VA 23185.ORCID 0000-0002-1493-0896
Cameron J GroverDepartment of Applied Science, Integrated Science Center, William & Mary, Williamsburg, VA 23185.ORCID 0000-0003-4146-2271
Gregory D Conradi SmithDepartment of Applied Science, Integrated Science Center, William & Mary, Williamsburg, VA 23185.ORCID 0000-0002-1054-6790
Christopher A Del NegroDepartment of Applied Science, Integrated Science Center, William & Mary, Williamsburg, VA 23185 cadeln@wm.edu.ORCID 0000-0002-7848-8224

Funding

Neurophysiology of breathing behavior in neonatal mice in vitroR01HL104127 · NHLBI · COLLEGE OF WILLIAM AND MARY · PI DEL NEGRO, CHRISTOPHER A. · 2010 to 2018
$2.6M
Ion Channel Mechanisms of Inspiratory Breathing Movements in MiceR01NS107296 · NINDS · COLLEGE OF WILLIAM AND MARY · PI DEL NEGRO, CHRISTOPHER A. · 2019 to 2022
$1.1M
CRCNS: Discovering the Neural Mechanisms of Breathing Rhythms - Eupnea and Sigh R01AT010816 · NCCIH · COLLEGE OF WILLIAM AND MARY · PI CONRADI SMITH, GREGORY DOUGLAS, DEL NEGRO, CHRISTOPHER A. · 2019 to 2021
$522k
NCCIH NIH HHS R01 AT010816NHLBI NIH HHS R01 HL104127NINDS NIH HHS R01 NS107296
6 · The paper itself

Abstract

The preBötzinger complex (preBötC) gives rise to two types of breathing behavior under normal physiological conditions: eupnea and sighing. Here, we examine the neural mechanisms that couple their underlying rhythms. We measured breathing in awake intact adult mice and recorded inspiratory rhythms from the preBötC in neonatal mouse brainstem slice preparations. We show previously undocumented variability in the temporal relationship between sigh breaths or bursts and their preceding eupneic breaths or inspiratory bursts. Investigating the synaptic mechanisms for this variability

Indexed as

RespirationRespiratory CenterAnimalsMicebreathingcentral pattern generatorpreBötzinger complex

Identifiers

PMID32393585
PMCPMC7363481

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.