Evidence map›Paper›PMID 32393580›Full record

ArticleThe Journal of biological chemistry2020

Andrew C Nelson, Thomas J Turbyville, Srisathiyanarayanan Dharmaiah, Megan Rigby, Rendong Yang, Ting-You Wang, John Columbus, Robert Stephens, Troy Taylor, Drew Sciacca and 6 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of biological chemistry, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.6field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 13 citations in OpenAlex.

  1. Article
  2. Article
  3. Multiplexed imaging for probing RAS-RAF interactions in living cells.Biochimica et biophysica acta. Biomembranes · 2023
    Article
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 2 institutions in 1 country.

Andrew C NelsonDepartment of Laboratory Medicine & Pathology, University of Minnesota, Minneapolis, Minnesota, USA nels2055@umn.edu dhirendra.simanshu@nih.gov emil-lou@umn.edu.ORCID 0000-0002-4741-0010
Thomas J TurbyvilleNCI RAS Initiative, Frederick National Laboratory for Cancer Research, Leidos Biomedical Research, Inc., Frederick, Maryland, USA.
Srisathiyanarayanan DharmaiahNCI RAS Initiative, Frederick National Laboratory for Cancer Research, Leidos Biomedical Research, Inc., Frederick, Maryland, USA.ORCID 0000-0001-7630-3962
Megan RigbyNCI RAS Initiative, Frederick National Laboratory for Cancer Research, Leidos Biomedical Research, Inc., Frederick, Maryland, USA.
Rendong YangThe Hormel Institute, University of Minnesota, Austin, Minnesota, USA.ORCID 0000-0002-9512-2240
Ting-You WangThe Hormel Institute, University of Minnesota, Austin, Minnesota, USA.
John ColumbusNCI RAS Initiative, Frederick National Laboratory for Cancer Research, Leidos Biomedical Research, Inc., Frederick, Maryland, USA.
Robert StephensNCI RAS Initiative, Frederick National Laboratory for Cancer Research, Leidos Biomedical Research, Inc., Frederick, Maryland, USA.
Troy TaylorNCI RAS Initiative, Frederick National Laboratory for Cancer Research, Leidos Biomedical Research, Inc., Frederick, Maryland, USA.
Drew SciaccaDepartment of Laboratory Medicine & Pathology, University of Minnesota, Minneapolis, Minnesota, USA.
Getiria OnsongoDepartment of Laboratory Medicine & Pathology, University of Minnesota, Minneapolis, Minnesota, USA.
Anne SarverDepartment of Surgery, University of Minnesota, Minneapolis, Minnesota, USA.
Subbaya SubramanianDepartment of Surgery, University of Minnesota, Minneapolis, Minnesota, USA.ORCID 0000-0002-2544-480X
Dwight V NissleyNCI RAS Initiative, Frederick National Laboratory for Cancer Research, Leidos Biomedical Research, Inc., Frederick, Maryland, USA.
Dhirendra K SimanshuNCI RAS Initiative, Frederick National Laboratory for Cancer Research, Leidos Biomedical Research, Inc., Frederick, Maryland, USA nels2055@umn.edu dhirendra.simanshu@nih.gov emil-lou@umn.edu.ORCID 0000-0002-9717-4618
Emil LouDepartment of Medicine, Division of Hematology, Oncology and Transplantation, University of Minnesota, Minneapolis, Minnesota, USA nels2055@umn.edu dhirendra.simanshu@nih.gov emil-lou@umn.edu.
Leidos (United States) · USUniversity of Minnesota · US

Funding

University of Minnesota Clinical and Translational Science Institute (UMN CTSI)UL1TR000114 · NCATS · UNIVERSITY OF MINNESOTA · PI BLAZAR, BRUCE R · 2012 to 2015
$35.0M
User Training and OutreachP30GM124165 · NIGMS · CORNELL UNIVERSITY · PI Nozomi Ando, J Christopher Fromme · 2018 to 2026
$34.2M
Pixel Array Detector for Macromolecular CrystallographyS10OD021527 · OD · CORNELL UNIVERSITY · PI EALICK, STEVEN E · 2016 to 2016
$2.0M
CCR NIH HHS HHSN261200800001CNCATS NIH HHS UL1 TR000114NCI NIH HHS HHSN261200800001ENIGMS NIH HHS P30 GM124165NIH HHS S10 OD021527
6 · The paper itself

Abstract

The oncogene RAS is one of the most widely studied proteins in cancer biology, and mutant active RAS is a driver in many types of solid tumors and hematological malignancies. Yet the biological effects of different

Indexed as

Colorectal NeoplasmsGTP PhosphohydrolasesMAP Kinase Signaling SystemMembrane ProteinsMutationProto-Oncogene Proteins p21(ras)Crystallography, X-RayExome SequencingHEK293 CellsHumansProtein DomainsProto-Oncogene Masraf KinasesGTP PhosphohydrolasesKRAS protein, humanMAS1 protein, humanMembrane ProteinsNRAS protein, humanProto-Oncogene MasProto-Oncogene Proteins p21(ras)raf Kinasesbedside-to-bench analysiscolon cancerexome sequencingoncogenepersonalized medicineprotein structureRAS proteinstructural biologyswitch II domaintandem duplication

Identifiers

PMID32393580
PMCPMC7363148
OpenAlexW3023448647

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.