Evidence map›Paper›PMID 32393499›Full record

ArticleAntimicrobial agents and chemotherapy2020

Insights into the l,d-Transpeptidases and d,d-Carboxypeptidase of Mycobacterium abscessus: Ceftaroline, Imipenem, and Novel Diazabicyclooctane Inhibitors.

Khalid M Dousa, Sebastian G Kurz, Magdalena A Taracila, Tracey Bonfield, Christopher R Bethel, Melissa D Barnes, Suresh Selvaraju, Ayman M Abdelhamed, Barry N Kreiswirth, W Henry Boom and 3 more

Abstract read
In one paragraph

Article in Antimicrobial agents and chemotherapy, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers.

0numbers the graph read from it
0cells of the map it votes in
44citing papers in PubMed
3.1field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

44 citing papers in PubMed, 57 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Optimizing target inactivation to treat multidrug-resistantAntimicrobial agents and chemotherapy · 2026
    Article
  5. Article
  6. Article
  7. The Role of β-Lactam Antibiotics in Treating Mycobacterium abscessus: From Laboratory Insights to Clinical Applications and the Case for Clinical Trials.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2026
    Review
  8. Article
  9. Article
  10. Article
  11. Article
  12. Oral β-lactam combinations are effectiveMicrobiology spectrum · 2025
    Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Novel C5α-substituted carbapenems enhanceAntimicrobial agents and chemotherapy · 2025
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 7 institutions in 1 country.

Khalid M Dousa *Division of Infectious Diseases & HIV Medicine, University Hospitals Cleveland Medical Center, Case Western Reserve University, Cleveland, Ohio, USA.ORCID 0000-0003-3272-7231
Sebastian G Kurz *Mount Sinai National Jewish Health Respiratory Institute, New York, New York, USA.
Magdalena A TaracilaResearch Service, Louis Stokes Cleveland Department of Veterans Affairs Medical Center, Cleveland, Ohio, USA.
Tracey BonfieldDepartment of Medicine, Case Western Reserve University School of Medicine, Cleveland, Ohio, USA.
Christopher R BethelResearch Service, Louis Stokes Cleveland Department of Veterans Affairs Medical Center, Cleveland, Ohio, USA.
Melissa D BarnesResearch Service, Louis Stokes Cleveland Department of Veterans Affairs Medical Center, Cleveland, Ohio, USA.
Suresh SelvarajuDepartment of Microbiology, MetroHealth Medical Center, Cleveland, Ohio, USA.
Ayman M AbdelhamedDepartment of Pathology, Case Western Reserve University School of Medicine, Cleveland, Ohio, USA.
Barry N KreiswirthCenter for Discovery and Innovation, Hackensack Meridian Health, Nutley, New Jersey, USA.
W Henry BoomDivision of Infectious Diseases & HIV Medicine, University Hospitals Cleveland Medical Center, Case Western Reserve University, Cleveland, Ohio, USA.
Shannon H KasperbauerDivision of Mycobacterial and Respiratory Infections, National Jewish Health, Denver, Colorado, USA.
Charles L DaleyDivision of Mycobacterial and Respiratory Infections, National Jewish Health, Denver, Colorado, USA.
Robert A BonomoResearch Service, Louis Stokes Cleveland Department of Veterans Affairs Medical Center, Cleveland, Ohio, USA robert.bonomo@va.gov.
Louis Stokes Cleveland VA Medical Center · USNational Jewish Health · USUniversity Hospitals of Cleveland · USUniversity School · USGeriatric Research Education and Clinical Center · USHackensack Meridian Health · USMetroHealth · US

Funding

Understanding B-Lactam Resistance in Acinetobacter baumanniiR01AI072219 · NIAID · CASE WESTERN RESERVE UNIVERSITY · PI ROBERT A. BONOMO, Philip N. Rather · 2007 to 2026
$6.6M
Dissecting the molecular targets to overcome beta-lactam resistance in M. abscessus complexR01AI141805 · NIAID · HACKENSACK UNIVERSITY MEDICAL CENTER · PI BARRY Neal KREISWIRTH · 2019 to 2026
$5.1M
Understanding ceftazidime resistance in SHV B-LactamasesR01AI063517 · NIAID · CASE WESTERN RESERVE UNIVERSITY · PI BONOMO, ROBERT A. · 2005 to 2023
$4.9M
A Mechanism-Based Approach to Metallo-beta-Lactamase InhibitionR01AI100560 · NIAID · CASE WESTERN RESERVE UNIVERSITY · PI BONOMO, ROBERT A., SPENCER, JAMES · 2012 to 2022
$4.4M
The Continuing Challenge of Carbapenemases in K. pneumoniae: KPC-2 & NDM-1I01BX001974 · VA · LOUIS STOKES CLEVELAND VA MEDICAL CENTER · PI BONOMO, ROBERT A. · 2013 to 2024
–
BLRD VA I01 BX001974NIAID NIH HHS R01 AI063517NIAID NIH HHS R01 AI072219NIAID NIH HHS R01 AI100560NIAID NIH HHS R01 AI141805
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Mycobacterium abscessusPeptidyl TransferasesAnti-Bacterial AgentsAzabicyclo Compoundsbeta-Lactamase InhibitorsCarboxypeptidasesCeftarolineCephalosporinsImipenemMicrobial Sensitivity TestsAnti-Bacterial AgentsAzabicyclo Compoundsbeta-Lactamase InhibitorsCarboxypeptidasesCeftarolineCephalosporinsImipenemPeptidyl Transferasesantibiotic resistanceantibioticsbacteriaceftarolinediazabicyclooctaneimipeneminhibitormycobacteriaMycobacterium abscessus

Identifiers

PMID32393499
PMCPMC7526840
OpenAlexW3024254663

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.