ArticleBMC psychiatry2020
Psychiatric disorders risk in patients with iron deficiency anemia and association with iron supplementation medications: a nationwide database analysis.
Article in BMC psychiatry, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 52 papers.
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Who cites it
52 citing papers in PubMed, 89 citations in OpenAlex.
- Safety and efficacy of Ninjin'yoeito along with iron supplementation therapy for preoperative anemia, fatigue, and anxiety in patients with gynecological disease: an open-label, single-center, randomized phase-II trial.BMC women's health · 2022Trial
- Effects of Schizophrenia, Bipolar Disorder, and Depression on Cardiopulmonary and Abdominal Organ Structure.Biological psychiatry global open science · 2026Article
- Nutritional biomarkers and three-month symptom changes in antidepressant-free adolescents with major depressive disorder: a retrospective cohort study.BMC pediatrics · 2026Article
- Micronutrient-immune interactions in mood and psychotic disorders: a case-control study of vitamin C, iron, zinc, magnesium, and peripheral blood cell indices.Scientific reports · 2026Article
- The Relationship Between Trace Elements and Depression.Nutrients · 2026Review
- School-Based Weekly Iron-Folic Acid Supplementation and Its Effect on Mental Health Outcomes Among Adolescent Girls in Central Ethiopia: A Cluster-Randomized Controlled Trial.Journal of nutrition and metabolism · 2026Article
- Efficacy of vitamin/mineral supplement on children with Down syndrome and autism spectrum disorder.International journal of developmental disabilities · 2026Article
- Mediating effects of physical activity, BMI, and dietary iron intake on the relationship between depression and chronic headaches.Scientific reports · 2025Article
- Brain iron distribution in transdiagnostic mental health burden.PCN reports : psychiatry and clinical neurosciences · 2025Article
- Nutrition and non-nutrition determinants of maternal mental disorders, stress and depression in pregnancy amidst a global pandemic: findings from Action against Stunting Hub Indonesia.The British journal of nutrition · 2025Article
- Prevalence and Severity of Depression Among Patients With Anemia Attending a Rural Outpatient Clinic in Faridabad, India: A Cross-sectional Study.Journal of preventive medicine and public health = Yebang Uihakhoe chi · 2025Article
- A case of depression with psychotic features associated with hemoglobin Manukau mutation.PCN reports : psychiatry and clinical neurosciences · 2025Article
- Iron, Emotion, and Awareness: Exploring Alexithymia and Anxiety in Anemic Women.Medicina (Kaunas, Lithuania) · 2025Article
- The effect of the COVID-19 pandemic on epistaxis and anaemia in patients with hereditary haemorrhagic telangiectasia (HHT) in central South Africa.Orphanet journal of rare diseases · 2025Observational
- Ferroptosis as a potential molecular mechanism of bipolar disorder.Translational psychiatry · 2025Review
- Sleep Quality, Depression, and the Risk of Anaemia in Adolescents Aged 10-19 Years During One Year of the COVID-19 Pandemic in Indonesia.Stress and health : journal of the International Society for the Investigation of Stress · 2025Article
- Pregnant women's sleep quality and its associated factors among antenatal care attendants in Bahir Dar City, Northwest Ethiopia.Scientific reports · 2025Article
- Anemia: Etiology, Pathophysiology, Impact, and Prevention: A Review.Iranian journal of public health · 2025Review
- Prevalence, sub-types, and associated factors of anemia among inpatients at a tertiary psychiatric hospital in Tanzania: a cross-sectional study.BMC psychiatry · 2025Article
- Depression and Anxiety Among Adolescents in Northern Sudan: A School-Based Cross-Sectional Study.Medicina (Kaunas, Lithuania) · 2025Article
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundIt has been shown that iron deficiency anemia (IDA) is associated with psychosocial consequences and psychiatric morbidity. However, the association between adults with IDA and psychiatric disorders has not been clarified. The purpose of this study was to investigate the psychiatric disorder morbidity of an IDA group in comparison with a non-IDA group and to examine the risk of psychiatric disorders in IDA patients treated with iron supplementation.
methodsAll study subjects were 20 years of age or over with newly diagnosed IDA enrolled in the Taiwan National Health Insurance Database from 2000 to 2012. We matched IDA and non-IDA subjects according to age and gender in a 1:2 ratio. Our primary outcome was diagnosis of psychiatric disorders and the patients were monitored until the end of 2013. A multivariate Cox proportional hazards regression model was used to explore the risk of psychiatric disorders in patients with IDA after adjustment for confounders, including demographic characteristics and comorbidities.
resultsThe adjusted hazard ratios (aHRs) of psychiatric disorders was 1.52 (95% CI = 1.45-1.59) in the IDA group compared with the non-IDA group. Among the different types of psychiatric disorders, the IDA group was associated with significantly higher incidence and risks of anxiety disorders, depression, sleep disorders, and psychotic disorders (p < 0.05). Furthermore, iron supplementation in IDA subjects was associated with a significantly lower risk of psychiatric disorders compared to non-iron supplementation in IDA patients.
conclusionsOur study indicates that IDA subjects had an increased risk of psychiatric disorders, regardless of other confounders. In IDA patients, iron supplementation was associated with a decreased risk of psychiatric disorders. Moreover, IDA patients receiving iron supplementation also had a lower risk of sleep disorders.
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