ReviewMolecular autism2020
Exploring the mechanisms underlying excitation/inhibition imbalance in human iPSC-derived models of ASD.
Review in Molecular autism, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
48 citing papers in PubMed, 70 citations in OpenAlex.
- CRISPR-Enabled functional genomics in hPSCs-derived neural models for autism spectrum disorder.Metabolic brain disease · 2026Review
- Smart sensing the spectrum: cutting-edge biosensor and biomarker approaches for early autism detection.Metabolic brain disease · 2026Review
- Autism subtypes identified using cross-species functional connectivity analyses.Nature neuroscience · 2026Article
- Hypoactivity, abnormal development of dendrites relevant to impaired synaptic transmission of calretinin-expressing interneurons in the medial prefrontal cortex underlies social deficits of mouse model in autism.Translational psychiatry · 2026Article
- Converging neurotrophic-immune signaling in autism spectrum disorder: integrative roles of klotho, GDNF/GFRA-1, IGF-1 and GLP-1 pathways.Metabolic brain disease · 2026Review
- Teaching developmental neurobiology with inclusion and valuing of neurodivergent learners.Developmental biology · 2026Review
- Beta power as a neural correlate of sensory features in autistic individuals.Journal of neurodevelopmental disorders · 2026Article
- Maternal pesticide exposure disrupts local inhibitory circuits in the reward pathway.Environment international · 2026Article
- Cerebellar Abnormalities: A Component of Autism Pathophysiology.Medicina (Kaunas, Lithuania) · 2026Review
- Sensory abnormalities in autism spectrum disorder and their in vitro modeling.Translational psychiatry · 2025Review
- Blood-based DNA methylation markers for autism spectrum disorder identification using machine learning.Epigenomics · 2025Article
- Developmental Disturbances in Animal Models of Autism Spectrum Disorder.Developmental neurobiology · 2025Review
- scDown: A Pipeline for Single-Cell RNA-Seq Downstream Analysis.International journal of molecular sciences · 2025Article
- Multimodal Correspondence between Optogenetic fMRI, Electrophysiology, and Anatomical Maps of the Secondary Somatosensory Cortex in Nonhuman Primates.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- High neural noise in autism: A hypothesis currently at the nexus of explanatory power.Heliyon · 2024Review
- GABA and glutamate measurements in temporal cortex of autistic children.Autism research : official journal of the International Society for Autism Research · 2024Article
- A fast and responsive voltage indicator with enhanced sensitivity for unitary synaptic events.Neuron · 2024Article
- New advances in the diagnosis and treatment of autism spectrum disorders.European journal of medical research · 2024Review
- Exploration of interictal to ictal transition in epileptic seizures using a neural mass model.Cognitive neurodynamics · 2024Article
- CNTN4 modulates neural elongation through interplay with APP.Open biology · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 2 countries.
Funding
Abstract
Autism spectrum disorder (ASD) is a range of neurodevelopmental disorders characterized by impaired social interaction and communication, and repetitive or restricted behaviors. ASD subjects exhibit complex genetic and clinical heterogeneity, thus hindering the discovery of pathophysiological mechanisms. Considering that several ASD-risk genes encode proteins involved in the regulation of synaptic plasticity, neuronal excitability, and neuronal connectivity, one hypothesis that has emerged is that ASD arises from a disruption of the neuronal network activity due to perturbation of the synaptic excitation and inhibition (E/I) balance. The development of induced pluripotent stem cell (iPSC) technology and recent advances in neuronal differentiation techniques provide a unique opportunity to model complex neuronal connectivity and to test the E/I hypothesis of ASD in human-based models. Here, we aim to review the latest advances in studying the different cellular and molecular mechanisms contributing to E/I balance using iPSC-based in vitro models of ASD.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.