Evidence map›Paper›PMID 32393342›Full record

ArticleBMC infectious diseases2020

Molecular identification and antifungal susceptibility profile of yeast from vulvovaginal candidiasis.

Yu Shi, Yuxia Zhu, Shangrong Fan, Xiaoping Liu, Yiheng Liang, Yingying Shan

Erratum issuedOpen access · goldAbstract read
In one paragraph

Article in BMC infectious diseases, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 16 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed, 1 pooled it
0.5field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 1 synthesis or guideline pooled it, 32 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Antifungal susceptibility and biofilm production of Candida species- causative agents of female genital tract infections.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2024
    Article
  6. Anticandidal Efficacy of Oral ProbiontIndian journal of microbiology · 2024
    Article
  7. Article
  8. Article
  9. Article
  10. Review
  11. Article
  12. Susceptibility to Clotrimazole ofPathogens (Basel, Switzerland) · 2021
    Article
  13. Article
  14. Distribution and antifungal susceptibility ofTherapeutic advances in infectious disease
    Article
  15. A Vulvovaginal Yeast Infection Caused byJournal of investigative medicine high impact case reports
    Article
  16. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Yu Shi *Department of Obstetrics and Gynecology, Peking University Shenzhen Hospital, Shenzhen, 518036, China.
Yuxia Zhu *Department of Obstetrics and Gynecology, Peking University Shenzhen Hospital, Shenzhen, 518036, China.
Shangrong FanDepartment of Obstetrics and Gynecology, Peking University Shenzhen Hospital, Shenzhen, 518036, China. fanshangrong@163.com.
Xiaoping LiuDepartment of Laboratory Science, Peking University Shenzhen Hospital, Shenzhen, 518036, China.
Yiheng LiangDepartment of Obstetrics and Gynecology, Peking University Shenzhen Hospital, Shenzhen, 518036, China.
Yingying ShanDepartment of Obstetrics and Gynecology, Peking University Shenzhen Hospital, Shenzhen, 518036, China.
Peking University Shenzhen Hospital · CNAnhui Medical University · CN

Funding

Science and Technology Planning Project of Shenzhen Municipality JCYJ20160428175005906Science and Technology Planning Project of Shenzhen Municipality JCYJ20180228162311024
6 · The paper itself

Abstract

backgroundAccurate identification Candida is important for successful therapy and epidemiology study. The aim of research is to study API 20C yeast identification system identification rate by using molecular identification as gold standard and tested the antifungal susceptibility of Candida from patients with vulvovaginal candidiasis (VVC).

methodsIn total, 3574 yeast isolates were obtained from patients with VVC. API 20C yeast identification, molecular identification and in vitro antifungal susceptibility were performed.

resultsC. albicans was the predominant Candida species [2748 isolates, 76.9%] in VVC. The isolates from vaginal samples represented 22 species based on molecular identification. The API 20C system identifies only 11 of the species encountered during the study period. Based on the API 20C system, 3273 (91.78%) isolates were correctly identified to the species level. The correct identification rate of the API 20C system for rare yeast was 15.29% (26/170 isolates). Antifungal susceptibility was tested in a total of 1844 isolates of Candida from patients with VVC. C. albicans was susceptible to most of the tested antifungals. The MICs of azoles for C. glabrata were higher than those for C. albicans. The MICs of echinocandins for C. parapsilosis were higher than those for C. albicans.

conclusionsThe API 20C yeast identification system can be used to reliably identify the most common Candida species while molecular methods are necessary for the identification of closely related, emerging, and rare yeast species. The results from this study suggest that much of the previous studies on the epidemiology of VVC should be re-thought. C. albicans was susceptible to most of the tested antifungals.

Indexed as

Drug Resistance, Multiple, FungalAdultAntifungal AgentsCandidaCandidiasis, VulvovaginalChinaFemaleHumansMicrobial Sensitivity TestsPolymerase Chain ReactionPrevalenceProspective StudiesYoung AdultAntifungal AgentsAntifungal susceptibilityCandidaCandidiasisIdentificationVulvovaginal

Identifiers

PMID32393342
PMCPMC7216708
OpenAlexW3027319621

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.