Evidence map›Paper›PMID 32393338›Full record

ArticleStem cell research & therapy2020

MSC-derived exosomes attenuate cell death through suppressing AIF nucleus translocation and enhance cutaneous wound healing.

Guifang Zhao, Feilin Liu, Zinan Liu, Kuiyang Zuo, Bo Wang, Yuying Zhang, Xing Han, Aobo Lian, Yuan Wang, Mingsheng Liu and 5 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Stem cell research & therapy, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 63 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
63citing papers in PubMed, 3 pooled it
11.0field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

63 citing papers in PubMed, 3 syntheses or guidelines pooled it, 130 citations in OpenAlex.

  1. Pooled it
  2. Role of Exosomes in Dermal Wound Healing: A Systematic Review.The Journal of investigative dermatology · 2022
    Pooled it
  3. Pooled it
  4. Review
  5. Review
  6. Review
  7. Molecules (Basel, Switzerland) · 2025
    Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Review
  14. Article
  15. Review
  16. Extracellular vesicles: innovative cell-free solutions for wound repair.Frontiers in bioengineering and biotechnology · 2025
    Review
  17. Exosomes from Different Sources in Promoting Wound Healing.Recent advances in drug delivery and formulation · 2025
    Review
  18. Article
  19. Article
  20. Article

3 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 2 institutions in 1 country.

Guifang ZhaoDepartment of Toxicology, School of Public Health, Jilin University, No. 1163 Xinmin Street, Changchun, Jilin, 130021, China.
Feilin LiuDepartment of Ophthalmology, the Second Hospital of Jilin University, Changchun, China.
Zinan LiuDepartment of Toxicology, School of Public Health, Jilin University, No. 1163 Xinmin Street, Changchun, Jilin, 130021, China.
Kuiyang ZuoDepartment of Toxicology, School of Public Health, Jilin University, No. 1163 Xinmin Street, Changchun, Jilin, 130021, China.
Bo WangDepartment of Toxicology, School of Public Health, Jilin University, No. 1163 Xinmin Street, Changchun, Jilin, 130021, China.
Yuying ZhangDepartment of Toxicology, School of Public Health, Jilin University, No. 1163 Xinmin Street, Changchun, Jilin, 130021, China.
Xing HanDepartment of Toxicology, School of Public Health, Jilin University, No. 1163 Xinmin Street, Changchun, Jilin, 130021, China.
Aobo LianDepartment of Toxicology, School of Public Health, Jilin University, No. 1163 Xinmin Street, Changchun, Jilin, 130021, China.
Yuan WangDepartment of Toxicology, School of Public Health, Jilin University, No. 1163 Xinmin Street, Changchun, Jilin, 130021, China.
Mingsheng LiuDepartment of Toxicology, School of Public Health, Jilin University, No. 1163 Xinmin Street, Changchun, Jilin, 130021, China.
Fei ZouDepartment of Toxicology, School of Public Health, Jilin University, No. 1163 Xinmin Street, Changchun, Jilin, 130021, China.
Pengdong LiDepartment of Toxicology, School of Public Health, Jilin University, No. 1163 Xinmin Street, Changchun, Jilin, 130021, China.
Xiaomei LiuDepartment of Toxicology, School of Public Health, Jilin University, No. 1163 Xinmin Street, Changchun, Jilin, 130021, China.
Minghua JinDepartment of Toxicology, School of Public Health, Jilin University, No. 1163 Xinmin Street, Changchun, Jilin, 130021, China.
Jin Yu LiuDepartment of Toxicology, School of Public Health, Jilin University, No. 1163 Xinmin Street, Changchun, Jilin, 130021, China. jy_liu@jlu.edu.cn.
Jilin University · CNSecond Affiliated Hospital of Jilin University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundSkin wounding is very common and may be slow to heal. Increasing evidence shows that exosomes derived from mesenchymal stem cells (MSCs) dramatically enhance skin wound healing in a paracrine manner. However, the mechanism underlying this phenomenon has not yet been elucidated. Thus, the objective of the present study was to identify the signaling pathways and paracrine factors by which MSC-derived exosomes promote de novo skin tissue regeneration in response to wound healing.

methodsIn vitro and in vivo skin wound healing models were created by treating immortalized human keratinocytes (HaCaT) with hydrogen peroxide (H

resultsThe hucMSC-Ex treatment significantly increased HaCaT cell proliferation and migration in a time- and dose-dependent manner, suppressed HaCaT apoptosis induced with H

conclusionsThese findings indicated that direct administration of hucMSC-Ex may effectively treat cutaneous wounding and could be of great value in clinical settings.

Indexed as

ExosomesAnimalsApoptosisApoptosis Inducing FactorCell ProliferationHydrogen PeroxideWound HealingApoptosis Inducing FactorHydrogen PeroxideApoptosisApoptosis-inducing factorExosomesMesenchymal stem cellsPoly (ADP-ribose) polymerase-1Protease-activated receptorSkin wound healing

Identifiers

PMID32393338
PMCPMC7212595
OpenAlexW3024594690

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.