ReviewCritical care (London, England)2020
Pulmonary complications associated with veno-arterial extra-corporeal membrane oxygenation: a comprehensive review.
Review in Critical care (London, England), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
41 citing papers in PubMed, 2 syntheses or guidelines pooled it, 73 citations in OpenAlex.
- The effects of mechanical ventilation during v-a ecmo support: a systematic review.Critical care (London, England) · 2026Pooled it
- Impact of left ventricular unloading timing on clinical outcomes in venoarterial extracorporeal membrane oxygenation: an updated systematic review and meta-analysis.BMC cardiovascular disorders · 2025Pooled it
- Recent advances in nanocellulose scaffold membranes: Sources, processing and functionalization.Materials today. Bio · 2026Review
- Article
- Short-Term Outcomes of Intra-Aortic Balloon Pump vs. Microaxial Flow Pump for Fulminant Myocarditis Supported by Venoarterial Extracorporeal Membrane Oxygenation.Circulation reports · 2026Article
- Passive versus active right ventricular support during lung transplantation: Insights from a porcine pulmonary ischemia-reperfusion injury model.JTCVS techniques · 2026Article
- Effect of femoro-axillary V-A ECMO flow on pulmonary capillary wedge pressure.Critical care (London, England) · 2026Article
- PD-1/TIGIT CD4⁺ T-Cell Signature for Risk Stratification of Post-Weaning Mortality in Venoarterial Extracorporeal Membrane Oxygenation Patients.Journal of inflammation research · 2026Article
- Time-critical VA-ECMO-facilitated resuscitation and recovery after acute myocardial infarction with cardiogenic shock and cardiac arrest: a case report.Frontiers in cardiovascular medicine · 2026Article
- Cardiogenic Shock Management in the Modern Era: A Narrative Review of Percutaneous Mechanical Circulatory Support Devices.Journal of cardiovascular development and disease · 2025Review
- Differential effect on acute pulmonary perfusion according to mechanical support in acute myocardial infarction cardiogenic shock: an acute animal model.Intensive care medicine experimental · 2025Article
- Effect of extracorporeal membrane oxygenation combined with hemoperfusion on inflammatory factors in patients with cardiogenic shock.World journal of cardiology · 2025Article
- Right-sided heart failure in acute respiratory distress syndrome.European respiratory review : an official journal of the European Respiratory Society · 2025Review
- Different Paths, Same Goals: A Comparative Study on the Safety of Femoral vs. Axillary Arterial Cannulation in VA ECMO.Journal of clinical medicine · 2025Article
- Global Trends in Extracorporeal Membrane Oxygenation Support for Circulatory Failure: A Bibliometric Analysis.Healthcare (Basel, Switzerland) · 2025Review
- COMPREHENSIVE CHARACTERIZATION OF CYTOKINES IN PATIENTS UNDER EXTRACORPOREAL MEMBRANE OXYGENATION: EVIDENCE FROM INTEGRATED BULK AND SINGLE-CELL RNA SEQUENCING DATA USING MULTIPLE MACHINE LEARNING APPROACHES.Shock (Augusta, Ga.) · 2025Article
- Early left heart decompression protects the lungs in a canine model of acute left heart failure being treated with venoarterial extracorporeal membrane oxygenation.Frontiers in cardiovascular medicine · 2025Article
- Traumatic Bronchus Avulsion Managed With Extracorporeal Membrane Oxygenation, Pneumonectomy, and Rib Fixation.Case reports in surgery · 2025Article
- Hemoadsorption improves kidney microcirculatory oxygenation and oxygen consumption, ameliorates tubular injury, and improves kidney function in a rat model of sepsis-induced AKI.Scientific reports · 2024Article
- Organ donation after extracorporeal cardiopulmonary resuscitation: a nationwide retrospective cohort study.Critical care (London, England) · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Veno-arterial extracorporeal membrane oxygenation (VA-ECMO) is a life-saving technology that provides transient respiratory and circulatory support for patients with profound cardiogenic shock or refractory cardiac arrest. Among its potential complications, VA-ECMO may adversely affect lung function through various pathophysiological mechanisms. The interaction of blood components with the biomaterials of the extracorporeal membrane elicits a systemic inflammatory response which may increase pulmonary vascular permeability and promote the sequestration of polymorphonuclear neutrophils within the lung parenchyma. Also, VA-ECMO increases the afterload of the left ventricle (LV) through reverse flow within the thoracic aorta, resulting in increased LV filling pressure and pulmonary congestion. Furthermore, VA-ECMO may result in long-standing pulmonary hypoxia, due to partial shunting of the pulmonary circulation and to reduced pulsatile blood flow within the bronchial circulation. Ultimately, these different abnormalities may result in a state of persisting lung inflammation and fibrotic changes with concomitant functional impairment, which may compromise weaning from VA-ECMO and could possibly result in long-term lung dysfunction. This review presents the mechanisms of lung damage and dysfunction under VA-ECMO and discusses potential strategies to prevent and treat such alterations.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.