Evidence map›Paper›PMID 32392745›Full record

ArticleCells2020

Large-Scale Profiling of Signaling Pathways Reveals a Distinct Demarcation between Normal and Extended Liver Resection.

Pieter Borger, Anton Buzdin, Maksim Sorokin, Ekaterina Kachaylo, Bostjan Humar, Rolf Graf, Pierre-Alien Clavien

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cells, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.6field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 4 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Pieter BorgerSwiss Hepato-Pancreatico-Biliary and Transplantation Center, Department of Surgery & Transplantation, University Hospital Zurich, Rämistrasse 100, CH-8091 Zürich, Switzerland.
Anton BuzdinShemyakin-Ovchinnikov Institute of Bioorganic Chemistry, 117198 Moscow, Russia.
Maksim SorokinShemyakin-Ovchinnikov Institute of Bioorganic Chemistry, 117198 Moscow, Russia.
Ekaterina KachayloSwiss Hepato-Pancreatico-Biliary and Transplantation Center, Department of Surgery & Transplantation, University Hospital Zurich, Rämistrasse 100, CH-8091 Zürich, Switzerland.
Bostjan HumarSwiss Hepato-Pancreatico-Biliary and Transplantation Center, Department of Surgery & Transplantation, University Hospital Zurich, Rämistrasse 100, CH-8091 Zürich, Switzerland.
Rolf GrafSwiss Hepato-Pancreatico-Biliary and Transplantation Center, Department of Surgery & Transplantation, University Hospital Zurich, Rämistrasse 100, CH-8091 Zürich, Switzerland.ORCID 0000-0001-7449-7302
Pierre-Alien ClavienSwiss Hepato-Pancreatico-Biliary and Transplantation Center, Department of Surgery & Transplantation, University Hospital Zurich, Rämistrasse 100, CH-8091 Zürich, Switzerland.
Institute of Bioorganic Chemistry · RUSechenov University · RU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Despite numerous studies addressing normal liver regeneration, we still lack comprehensive understanding of the biological processes underlying failed liver regeneration. Therefore, we analyzed the activity of 271 intracellular signaling pathways (ISPs) by genome wide profiling of differentially expressed RNAs in murine liver tissue biopsies after normal hepatectomy (nHx; 68% of liver removed) and extended hepatectomy (eHx; 86% of liver removed). Comprehensive, genome-wide transcriptome profiling using RNAseq was performed in liver tissue obtained from mice (sham, nHx, and eHx) harvested 1, 8, 16, 32, and 48 h after operation (n = 3 per group) and the OncoFinder toolkit was used for an unsupervised, unbiased identification of intracellular signaling pathways (ISP) activity. We observed that the normal regenerative process requires a transient activation and silencing of approximately two dozen of ISPs. After nHx, the

Indexed as

Gene Expression ProfilingAnimalsHepatectomyLiverMice, Inbred C57BLMicroRNAsRNA, MessengerSignal TransductionTime FactorsTranscriptomeMicroRNAsRNA, Messengerextended liver resectionintracellular signaling pathwaysliver failurenormal liver resectionOncofinderRNAseqsmall-for-size syndrome

Identifiers

PMID32392745
PMCPMC7290735
OpenAlexW3022338190

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.