Evidence map›Paper›PMID 32392559›Full record

ReviewActa haematologica2021

Treating Leukemia in the Time of COVID-19.

Shilpa Paul, Caitlin R Rausch, Nitin Jain, Tapan Kadia, Farhad Ravandi, Courtney D DiNardo, Mary Alma Welch, Bouthaina S Dabaja, Naval Daver, Guillermo Garcia-Manero and 8 more

Open access · bronzeAbstract readReview
In one paragraph

Review in Acta haematologica, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.

0numbers the graph read from it
0cells of the map it votes in
41citing papers in PubMed
8.8field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

41 citing papers in PubMed, 79 citations in OpenAlex.

  1. Review
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  13. Evaluation of COVID-19 vaccine response in patients with cancer: An interim analysis.European journal of cancer (Oxford, England : 1990) · 2021
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors at 1 institution in 1 country.

Shilpa PaulDivision of Pharmacy, University of Texas MD Anderson Cancer Center, Houston, Texas, USA.
Caitlin R RauschDivision of Pharmacy, University of Texas MD Anderson Cancer Center, Houston, Texas, USA.
Nitin JainDepartment of Leukemia, University of Texas MD Anderson Cancer Center, Houston, Texas, USA.
Tapan KadiaDepartment of Leukemia, University of Texas MD Anderson Cancer Center, Houston, Texas, USA.
Farhad RavandiDepartment of Leukemia, University of Texas MD Anderson Cancer Center, Houston, Texas, USA.
Courtney D DiNardoDepartment of Leukemia, University of Texas MD Anderson Cancer Center, Houston, Texas, USA.
Mary Alma WelchDepartment of Leukemia, University of Texas MD Anderson Cancer Center, Houston, Texas, USA.
Bouthaina S DabajaDepartment of Radiation Oncology, University of Texas MD Anderson Cancer Center, Houston, Texas, USA.
Naval DaverDepartment of Leukemia, University of Texas MD Anderson Cancer Center, Houston, Texas, USA.
Guillermo Garcia-ManeroDepartment of Leukemia, University of Texas MD Anderson Cancer Center, Houston, Texas, USA.
William WierdaDepartment of Leukemia, University of Texas MD Anderson Cancer Center, Houston, Texas, USA.
Naveen PemmarajuDepartment of Leukemia, University of Texas MD Anderson Cancer Center, Houston, Texas, USA.
Guillermo Montalban BravoDepartment of Leukemia, University of Texas MD Anderson Cancer Center, Houston, Texas, USA.
Philip ThompsonDepartment of Leukemia, University of Texas MD Anderson Cancer Center, Houston, Texas, USA.
Srdan VerstovsekDepartment of Leukemia, University of Texas MD Anderson Cancer Center, Houston, Texas, USA.
Marina KonoplevaDepartment of Leukemia, University of Texas MD Anderson Cancer Center, Houston, Texas, USA.
Hagop KantarjianDepartment of Leukemia, University of Texas MD Anderson Cancer Center, Houston, Texas, USA.
Elias JabbourDepartment of Leukemia, University of Texas MD Anderson Cancer Center, Houston, Texas, USA, ejabbour@mdanderson.org.
The University of Texas MD Anderson Cancer Center · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The coronavirus disease 2019 (COVID-19) pandemic poses several challenges to the management of patients with leukemia. The biology of each leukemia and its corresponding treatment with conventional intensive chemotherapy, with or without targeted therapies (venetoclax, FLT3 inhibitors, IDH1/2 inhibitors, Bruton's tyrosine kinase inhibitors), introduce additional layers of complexity during COVID-19 high-risk periods. The knowledge about COVID-19 is accumulating rapidly. An important distinction is the prevalence of "exposure" versus "clinical infectivity," which determine the risk versus benefit of modifying potentially highly curative therapies in leukemia. At present, the rate of clinical infection is <1-2% worldwide. With a mortality rate of 1-5% in CO-VID-19 patients in the general population and potentially of >30% in patients with cancer, careful consideration should be given to the risk of COVID-19 in leukemia. Instead of reducing patient access to specialized cancer centers and modifying therapies to ones with unproven curative benefit, there is more rationale for less intensive, yet effective therapies that may require fewer clinic visits or hospitalizations. Here, we offer recommendations on the optimization of leukemia management during high-risk COVID-19 periods.

Indexed as

SARS-CoV-2Acute DiseaseAntineoplastic Combined Chemotherapy ProtocolsChronic DiseaseCOVID-19HumansLeukemiaMyelodysplastic SyndromesMyeloproliferative DisordersPandemicsRisk FactorsAcute leukemiaChronic leukemiaCOVID-19Myelodysplastic syndrome

Identifiers

PMID32392559
PMCPMC7270066
OpenAlexW3022796443

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.