ArticleCell2020
Structural and Proteomic Characterization of the Initiation of Giant Virus Infection.
Article in Cell, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
31 citing papers in PubMed.
- Infection cycles of viruses of the phylum Nucleocytoviricota.Nature reviews. Microbiology · 2026Review
- Vicennial metagenomic time series unveils evolutionary dynamics of giant viruses in a freshwater ecosystem.Nature communications · 2026Article
- Many paths, similar destinations: viruses and bacterial microcompartments form polyhedra inside cells.Journal of virology · 2026Review
- Elucidating the protein interaction network of one of the largest icosahedral capsids in the virosphere.The EMBO journal · 2026Article
- The proteomics of the giant cedratvirus particles reveals unique and shared features with pitho-like viruses.Journal of virology · 2025Article
- Article
- Intracellular iron positively modulates the replicative cycle of mimiviruses, increasing virus production.Journal of virology · 2025Article
- Evolutionarily conserved grammar rules viral factories of amoeba-infecting members of the hyperdiverseProceedings of the National Academy of Sciences of the United States of America · 2025Article
- Biological properties and genomic analysis of the fourth strain of molliviruses encoding a eukaryotic-like transmembrane transport protein.Virology journal · 2025Article
- Penton blooming, a conserved mechanism of genome delivery used by disparate microviruses.mBio · 2025Article
- Conserved marseilleviruses harboring diverse antibiotic resistance genes isolated from the Yangtze river Delta and the Pearl river delta, China.Scientific reports · 2025Article
- Review
- Giant viruses inhibit superinfection by downregulating phagocytosis inJournal of virology · 2024Article
- A giant virus infecting the amoeboflagellate Naegleria.Nature communications · 2024Article
- Structure and replication cycle of a virus infecting climate-modulating algaScience advances · 2024Article
- Unexpected thermal stability of two enveloped megaviruses, Emiliania huxleyi virus and African swine fever virus, as measured by viability PCR.Virology journal · 2024Article
- Functional redundancy revealed by the deletion of the mimivirus GMC-oxidoreductase genes.microLife · 2024Article
- Cytopathic effects in Mimivirus infection: understanding the kinetics of virus-cell interaction.Memorias do Instituto Oswaldo Cruz · 2024Article
- Assessing the biogeography of marine giant viruses in four oceanic transects.ISME communications · 2023Article
- Assessing the biogeography of marine giant viruses in four oceanic transects.bioRxiv : the preprint server for biology · 2023Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
Since their discovery, giant viruses have expanded our understanding of the principles of virology. Due to their gargantuan size and complexity, little is known about the life cycles of these viruses. To answer outstanding questions regarding giant virus infection mechanisms, we set out to determine biomolecular conditions that promote giant virus genome release. We generated four infection intermediates in Samba virus (Mimivirus genus, lineage A) as visualized by cryoelectron microscopy (cryo-EM), cryoelectron tomography (cryo-ET), and scanning electron microscopy (SEM). Each of these four intermediates reflects similar morphology to a stage that occurs in vivo. We show that these genome release stages are conserved in other mimiviruses. Finally, we identified proteins that are released from Samba and newly discovered Tupanvirus through differential mass spectrometry. Our work revealed the molecular forces that trigger infection are conserved among disparate giant viruses. This study is also the first to identify specific proteins released during the initial stages of giant virus infection.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.