Evidence map›Paper›PMID 32392393›Full record

ArticleAngewandte Chemie (International ed. in English)2020

Magnetic Micromotors for Multiple Motile Sperm Cells Capture, Transport, and Enzymatic Release.

Haifeng Xu, Mariana Medina-Sánchez, Oliver G Schmidt

Open access · hybridAbstract read
In one paragraph

Article in Angewandte Chemie (International ed. in English), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed
10.1field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

31 citing papers in PubMed, 106 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Review
  5. Recent Advances in Collective Behaviors of Micro/Nanomotor Swarms.Advanced materials (Deerfield Beach, Fla.) · 2026
    Review
  6. Transport of Adoptive Cell Transfers With Magnetic Helical Microrobots.Small (Weinheim an der Bergstrasse, Germany) · 2025
    Article
  7. MOF Coating Enhances the Ion Tolerance of Micromotors.Angewandte Chemie (International ed. in English) · 2025
    Article
  8. Review
  9. Review
  10. Review
  11. Article
  12. Magnetic Control of Nonmagnetic Living Organisms.ACS applied materials & interfaces · 2024
    Article
  13. Article
  14. Review
  15. Article
  16. Article
  17. Review
  18. Review
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  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Haifeng XuInstitute for Integrative Nanosciences, Leibniz IFW Dresden, Helmholtzstraße 20, 01069, Dresden, Germany.
Mariana Medina-SánchezInstitute for Integrative Nanosciences, Leibniz IFW Dresden, Helmholtzstraße 20, 01069, Dresden, Germany.ORCID 0000-0001-6149-3732
Oliver G SchmidtInstitute for Integrative Nanosciences, Leibniz IFW Dresden, Helmholtzstraße 20, 01069, Dresden, Germany.ORCID 0000-0001-9503-8367
Leibniz Institute for Solid State and Materials Research · DEChemnitz University of Technology · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

An integrated system combining a magnetically-driven micromotor and a synthetized protein-based hyaluronic acid (HA) microflake is presented for the in situ selection and transport of multiple motile sperm cells (ca. 50). The system appeals for targeted sperm delivery in the reproductive system to assist fertilization or to deliver drugs. The binding mechanism between the HA microflake and sperm relies on the interactions between HA and the corresponding sperm HA receptors. Once sperm are captured within the HA microflake, the assembly is trapped and transported by a magnetically-driven helical microcarrier. The trapping of the sperm-microflake occurs by a local vortex induced by the microcarrier during rotation-translation under a rotating magnetic field. After transport, the microflake is enzymatically hydrolyzed by local proteases, allowing sperm to escape and finally reach the target location. This cargo-delivery system represents a new concept to transport not only multiple motile sperm but also other actively moving biological cargoes.

Indexed as

HumansHyaluronic AcidMagnetic PhenomenaMaleSpermatozoaHyaluronic Acidenzymatic releasemature sperm selectionmicroflake synthesismicromotorsperm swarm transport

Identifiers

PMID32392393
PMCPMC7496921
OpenAlexW3023304357

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.