ArticlePloS one2020
Effect of experimental, morphological and mechanical factors on the murine spinal cord subjected to transverse contusion: A finite element study.
Article in PloS one, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 25 citations in OpenAlex.
- Article
- Spinal cord morphology and PKD2L1Frontiers in neuroanatomy · 2025Article
- Ultraflexible electrodes for recording neural activity in the mouse spinal cord during motor behavior.Cell reports · 2024Article
- Finite Element Analysis for Degenerative Cervical Myelopathy: Scoping Review of the Current Findings and Design Approaches, Including Recommendations on the Choice of Material Properties.JMIR biomedical engineering · 2024Article
- Finite element modeling of the human cervical spinal cord and its applications: A systematic review.North American Spine Society journal · 2023Review
- Intermediate gray matter interneurons in the lumbar spinal cord play a critical and necessary role in coordinated locomotion.PloS one · 2023Article
- The biomechanical implications of neck position in cervical contusion animal models of SCI.Frontiers in neurology · 2023Review
- Effect of mechanical stimulation on tissue heterotopic ossification: anFrontiers in physiology · 2023Article
- Intubation Biomechanics: Clinical Implications of Computational Modeling of Intervertebral Motion and Spinal Cord Strain during Tracheal Intubation in an Intact Cervical Spine.Anesthesiology · 2021Article
- Functional rewiring across spinal injuries via biomimetic nanofiber scaffolds.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Finite element models combined with animal experimental models of spinal cord injury provides the opportunity for investigating the effects of the injury mechanism on the neural tissue deformation and the resulting tissue damage. Thus, we developed a finite element model of the mouse cervical spinal cord in order to investigate the effect of morphological, experimental and mechanical factors on the spinal cord mechanical behavior subjected to transverse contusion. The overall mechanical behavior of the model was validated with experimental data of unilateral cervical contusion in mice. The effects of the spinal cord material properties, diameter and curvature, and of the impactor position and inclination on the strain distribution were investigated in 8 spinal cord anatomical regions of interest for 98 configurations of the model. Pareto analysis revealed that the material properties had a significant effect (p<0.01) for all regions of interest of the spinal cord and was the most influential factor for 7 out of 8 regions. This highlighted the need for comprehensive mechanical characterization of the gray and white matter in order to develop effective models capable of predicting tissue deformation during spinal cord injuries.
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