Evidence map›Paper›PMID 32391917›Full record

ArticleAllergy2020

Ovomucoid epitope-specific repertoire of IgE, IgG

Maria Suprun, Robert Getts, Galina Grishina, Angela Tsuang, Mayte Suárez-Fariñas, Hugh A Sampson

Open access · greenAbstract read
In one paragraph

Article in Allergy, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
2.9field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 35 citations in OpenAlex.

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  7. Type 2 immunity in allergic diseases.Cellular & molecular immunology · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Maria SuprunIcahn School of Medicine at Mount Sinai, New Yok, NY, USA.ORCID 0000-0001-9161-4021
Robert GettsAllerGenis LLC, Hatfield, PA, USA.
Galina GrishinaIcahn School of Medicine at Mount Sinai, New Yok, NY, USA.
Angela TsuangIcahn School of Medicine at Mount Sinai, New Yok, NY, USA.
Mayte Suárez-FariñasIcahn School of Medicine at Mount Sinai, New Yok, NY, USA.
Hugh A SampsonIcahn School of Medicine at Mount Sinai, New Yok, NY, USA.ORCID 0000-0003-1613-8875
Icahn School of Medicine at Mount Sinai · USAllergan (United States) · US

Funding

Mechanistic CoreU19AI066738 · NIAID · MOUNT SINAI SCHOOL OF MEDICINE OF NYU · PI SICHERER, SCOTT H · 2005 to 2016
$43.6M
Teaching biomedical and pharmacological trainees to produce FAIR data for AI & ML applicationsT32GM062754 · NIGMS · MOUNT SINAI SCHOOL OF MEDICINE OF NYU · PI SCHLESSINGER, AVNER · 2001 to 2023
$6.2M
National Institute of Allergy and Infectious Diseases AI-66738NIAID NIH HHS U19 AI066738NIGMS NIH HHS T32 GM062754NIGMS NIH HHS T32GM062754
6 · The paper itself

Abstract

backgroundEgg-white ovomucoid, that is, Gal d 1, is associated with IgE-mediated allergic reactions in most egg-allergic children. Epitope-specific IgE levels have been correlated with the severity of egg allergy, while emerging evidence suggests that other antibody isotypes (IgG

methodsBead-based epitope assay (BBEA) was used to quantitate the levels of epitope-specific (es)IgA, esIgE, esIgD, esIgG

resultsBBEA had high reliability (ICC >0.75) and low variability (CV <20%) and could detect known IgE-binding epitopes. Egg-allergic children had lower esIgA

conclusionsCollectively, these data point toward a contribution of epitope-specific antibody repertoires to the pathogenesis of egg allergy.

Indexed as

Immunoglobulin EOvomucinAllergensChildEpitopesHumansImmunoglobulin AImmunoglobulin DImmunoglobulin GReproducibility of ResultsAllergensEpitopesImmunoglobulin AImmunoglobulin DImmunoglobulin EImmunoglobulin GOvomucinanaphylaxisantibody repertoireegg allergyepitopesovomucoid

Identifiers

PMID32391917
PMCPMC8158022
OpenAlexW3023257810

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.