ArticleGigaScience2020
Global ocean resistome revealed: Exploring antibiotic resistance gene abundance and distribution in TARA Oceans samples.
Article in GigaScience, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.
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Who cites it
40 citing papers in PubMed, 101 citations in OpenAlex.
- High Resistance and Biofilm Tolerance to Antimicrobials of Marine Bacteria From Brazilian Deep-Sea Sediment.Environmental microbiology reports · 2026Article
- Removal of coliform pollution using a gravel-packed contact bed: reduction effect and microbial community analysis.Water science and technology : a journal of the International Association on Water Pollution Research · 2025Article
- Effects of Salinity Fluctuation on Antimicrobial Resistance and Virulence Factor Genes of Low and High Nucleic Acid-Content Bacteria in a Marine Environment.Microorganisms · 2025Article
- The risk of pathogenicity and antibiotic resistance in deep-sea cold seep microorganisms.mSystems · 2025Article
- Identifying wastewater chemicals in coastal aerosols.Science advances · 2025Article
- Emerging Trends in Antimicrobial Resistance in Polar Aquatic Ecosystems.Antibiotics (Basel, Switzerland) · 2025Review
- Environmental drivers of the resistome across the Baltic Sea.Microbiome · 2025Article
- Global analysis of the metaplasmidome: ecological drivers and spread of antibiotic resistance genes across ecosystems.Microbiome · 2025Article
- Species-resolved profiling of antibiotic resistance genes in complex metagenomes through long-read overlapping with Argo.Nature communications · 2025Article
- The influence of depth on the global deep-sea plasmidome.Scientific reports · 2025Article
- From wastewater to resistance: characterization of multidrug-resistant bacteria and assessment of natural antimicrobial compounds.Frontiers in microbiology · 2025Article
- Deep-Sea Ecosystems as an Unexpected Source of Antibiotic Resistance Genes.Marine drugs · 2024Article
- Impact of salmon farming in the antibiotic resistance and structure of marine bacterial communities from surface seawater of a northern Patagonian area of Chile.Biological research · 2024Article
- Landscape of global urban environmental resistome and its association with local socioeconomic and medical status.Science China. Life sciences · 2024Article
- Plasmid-Borne Biosynthetic Gene Clusters within a Permanently Stratified Marine Water Column.Microorganisms · 2024Article
- Metagenomic exploration of Andaman region of the Indian Ocean.Scientific reports · 2024Article
- Persistence of Marine Bacterial Plasmid in the House Fly (Musca domestica): Marine-Derived Antimicrobial Resistance Genes Have a Chance of Invading the Human Environment.Microbial ecology · 2024Article
- Large-Scale Biogeographical Shifts of Abundance of Antibiotic Resistance Genes and Marine Bacterial Communities as Their Carriers along a Trophic Gradient.International journal of molecular sciences · 2024Article
- A comparative genomics study of the microbiome and freshwater resistome in Southern Pantanal.Frontiers in genetics · 2024Article
- Structure and dispersion of the conjugative mobilome in surface ocean bacterioplankton.ISME communications · 2024Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe rise of antibiotic resistance (AR) in clinical settings is of great concern. Therefore, the understanding of AR mechanisms, evolution, and global distribution is a priority for patient survival. Despite all efforts in the elucidation of AR mechanisms in clinical strains, little is known about its prevalence and evolution in environmental microorganisms. We used 293 metagenomic samples from the TARA Oceans project to detect and quantify environmental antibiotic resistance genes (ARGs) using machine learning tools.
resultsAfter manual curation of ARGs, their abundance and distribution in the global ocean are presented. Additionally, the potential of horizontal ARG transfer by plasmids and their correlation with environmental and geographical parameters is shown. A total of 99,205 environmental open reading frames (ORFs) were classified as 1 of 560 different ARGs conferring resistance to 26 antibiotic classes. We found 24,567 ORFs in putative plasmid sequences, suggesting the importance of mobile genetic elements in the dynamics of environmental ARG transmission. Moreover, 4,804 contigs with >=2 putative ARGs were found, including 2 plasmid-like contigs with 5 different ARGs, highlighting the potential presence of multi-resistant microorganisms in the natural ocean environment. Finally, we identified ARGs conferring resistance to some of the most relevant clinical antibiotics, revealing the presence of 15 ARGs similar to mobilized colistin resistance genes (mcr) with high abundance on polar biomes. Of these, 5 are assigned to Psychrobacter, a genus including opportunistic human pathogens.
conclusionsThis study uncovers the diversity and abundance of ARGs in the global ocean metagenome. Our results are available on Zenodo in MySQL database dump format, and all the code used for the analyses, including a Jupyter notebook js avaliable on Github. We also developed a dashboard web application (http://www.resistomedb.com) for data visualization.
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