Evidence map›Paper›PMID 32391877›Full record

ArticleEuropean heart journal2020

Characteristics and clinical significance of myocardial injury in patients with severe coronavirus disease 2019.

Shaobo Shi, Mu Qin, Yuli Cai, Tao Liu, Bo Shen, Fan Yang, Sheng Cao, Xu Liu, Yaozu Xiang, Qinyan Zhao and 3 more

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in European heart journal, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 306 papers, 25 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
306citing papers in PubMed, 25 pooled it
11.2field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

306 citing papers in PubMed, 25 syntheses or guidelines pooled it, 498 citations in OpenAlex.

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  10. Why do men have worse COVID-19-related outcomes? A systematic review and meta-analysis with sex adjusted for age.Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologica · 2022
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  13. Pre-existing atrial fibrillation is associated with increased mortality in COVID-19 Patients.Journal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing · 2021
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246 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

13 authors at 3 institutions in 1 country.

Shaobo ShiDepartment of Cardiology, Renmin Hospital of Wuhan University, Wuhan, 430060, China.
Mu QinDepartment of Cardiology, Shanghai Chest Hospital, Shanghai Jiaotong University, Shanghai, 200030, China.
Yuli CaiDepartment of Endocrinology, Renmin Hospital of Wuhan University, Wuhan, 430060, China.
Tao LiuDepartment of Cardiology, Renmin Hospital of Wuhan University, Wuhan, 430060, China.
Bo ShenDepartment of Cardiology, Renmin Hospital of Wuhan University, Wuhan, 430060, China.
Fan YangDepartment of Infectious Diseases, Renmin Hospital of Wuhan University, Wuhan, 430060, China.
Sheng CaoDepartment of Echocardiography, Renmin Hospital of Wuhan University, Wuhan, 430060, China.
Xu LiuDepartment of Cardiology, Shanghai Chest Hospital, Shanghai Jiaotong University, Shanghai, 200030, China.
Yaozu XiangShanghai East Hospital, School of Life Sciences and Technology, Advanced Institute of Translational Medicine, Tongji University, Shanghai, 200092, China.
Qinyan ZhaoDepartment of Cardiology, Renmin Hospital of Wuhan University, Wuhan, 430060, China.
He HuangDepartment of Cardiology, Renmin Hospital of Wuhan University, Wuhan, 430060, China.
Bo YangDepartment of Cardiology, Renmin Hospital of Wuhan University, Wuhan, 430060, China.
Congxin HuangDepartment of Cardiology, Renmin Hospital of Wuhan University, Wuhan, 430060, China.
Wuhan University · CNShanghai Chest Hospital · CNShanghai East Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimsTo investigate the characteristics and clinical significance of myocardial injury in patients with severe coronavirus disease 2019 (COVID-19). METHODS AND

resultsWe enrolled 671 eligible hospitalized patients with severe COVID-19 from 1 January to 23 February 2020, with a median age of 63 years. Clinical, laboratory, and treatment data were collected and compared between patients who died and survivors. Risk factors of death and myocardial injury were analysed using multivariable regression models. A total of 62 patients (9.2%) died, who more often had myocardial injury (75.8% vs. 9.7%; P < 0.001) than survivors. The area under the receiver operating characteristic curve of initial cardiac troponin I (cTnI) for predicting in-hospital mortality was 0.92 [95% confidence interval (CI), 0.87-0.96; sensitivity, 0.86; specificity, 0.86; P < 0.001]. The single cut-off point and high level of cTnI predicted risk of in-hospital death, hazard ratio (HR) was 4.56 (95% CI, 1.28-16.28; P = 0.019) and 1.25 (95% CI, 1.07-1.46; P = 0.004), respectively. In multivariable logistic regression, senior age, comorbidities (e.g. hypertension, coronary heart disease, chronic renal failure, and chronic obstructive pulmonary disease), and high level of C-reactive protein were predictors of myocardial injury.

conclusionThe risk of in-hospital death among patients with severe COVID-19 can be predicted by markers of myocardial injury, and was significantly associated with senior age, inflammatory response, and cardiovascular comorbidities.

Indexed as

BetacoronavirusAdultAgedAged, 80 and overBiomarkersChinaCoronavirus InfectionsCOVID-19FemaleFollow-Up StudiesHeart DiseasesHospital MortalityHumansLogistic ModelsMaleMiddle AgedBiomarkersCoronavirus disease 2019MortalityMyocardial injuryRisk

Identifiers

PMID32391877
PMCPMC7239100
OpenAlexW3023206311

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.