Evidence map›Paper›PMID 32391804›Full record

ArticleAging2020

Exosomal miRNA-34 from cancer-associated fibroblasts inhibits growth and invasion of gastric cancer cells

Liang Shi, Zhenyong Wang, Xiuchao Geng, Yuhao Zhang, Ziqing Xue

RetractedOpen access · greenAbstract readRetracted Publication
PubMed Full text at PMC Publisher
In one paragraph

Article in Aging, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It has been retracted, and should not be counted. Cited by 39 papers.

0numbers the graph read from it
0cells of the map it votes in
39citing papers in PubMed
4.2field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

39 citing papers in PubMed, 56 citations in OpenAlex.

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  11. The biological role of extracellular vesicles in gastric cancer metastasis.Frontiers in cell and developmental biology · 2024
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors at 5 institutions in 1 country.

Liang ShiEndoscope Room, Department of General Surgery, Cangzhou Central Hospital, Cangzhou 061001, Hebei Province, China.
Zhenyong WangThe First Department of General Surgery, Cangzhou Central Hospital, Cangzhou 061001, Hebei Province, China.
Xiuchao GengIntegrated Chinese and Western Medicine, Hebei University of Chinese Medicine, Shijiazhuang 050020, Hebei Province, China.
Yuhao ZhangDepartment of Neurosurgery, Affiliated hospital of Hebei university, Baoding 071000, Hebei Province, China.
Ziqing XueHebei University, Baoding 071002, Hebei Province, China.
Affiliated Hospital of Hebei University · CNCangzhou Central Hospital · CNHebei Medical University · CNHebei University · CNHebei University of Chinese Medicine · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Gastric cancer (GC) is one of the most common malignancies worldwide manifesting high morbidity and mortality. Cancer-associated fibroblasts (CAFs), important components of the tumor microenvironment, are essential for tumorigenesis and progression. Exosomes secreted from CAFs have been reported as the critical molecule-vehicle in intercellular crosstalk. However, the precise mechanism underlying the effect of CAFs remains to be fully investigated. In this study, we aimed to determine the role of CAFs and their exosomes in the progression of GC and related mechanisms. The results revealed that miRNA-34 was downregulated in both GC fibroblasts (GCFs) and GC cell lines while the overexpression of miRNA-34 suppressed the proliferation, invasion, and motility of GC cell lines. Coculturing GC cells with miRNA-34-overexpressing GCFs led to the suppression of cancer progression. Also, exosomes derived from GCFs were taken up by GC cells

Indexed as

AnimalsCancer-Associated FibroblastsCell MovementCell ProliferationCell Transformation, NeoplasticDisease ProgressionDown-RegulationExosomesGene Expression Regulation, NeoplasticHEK293 CellsHumansMaleMiceMice, Inbred C57BLMice, NudeMicroRNAsMicroRNAsMIRN34 microRNA, humancancer-associated fibroblastsexosomegastric cancermiRNA-34proliferation

Identifiers

PMID32391804
PMCPMC7244055
OpenAlexW3021681600

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.