Observational studyZhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences2020
[Clinical observation of 6 severe COVID-19 patients treated with plasma exchange or tocilizumab].
Observational study in Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
12 citing papers in PubMed, 1 synthesis or guideline pooled it, 31 citations in OpenAlex.
- Use of therapeutic plasma exchange in COVID-19: A systematic review of current evidence.Therapeutic apheresis and dialysis : official peer-reviewed journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy · 2022Pooled it
- Plasma exchange and COVID 19.Transfusion and apheresis science : official journal of the World Apheresis Association : official journal of the European Society for Haemapheresis · 2022Article
- Treatment of MIS-C in Children and Adolescents.Current pediatrics reports · 2022Review
- Algorithm for the diagnosis and management of the multisystem inflammatory syndrome in children associated with COVID-19.International journal of clinical practice · 2021Review
- Understanding the role of therapeutic plasma exchange in COVID-19: preliminary guidance and practices.Vox sanguinis · 2021Article
- Immunoregulatory therapy strategies that target cytokine storms in patients with COVID-19 (Review).Experimental and therapeutic medicine · 2021Review
- Potential of therapeutic plasmapheresis in treatment of COVID-19 patients: Immunopathogenesis and coagulopathy.Transfusion and apheresis science : official journal of the World Apheresis Association : official journal of the European Society for Haemapheresis · 2020Review
- The successful management of an elderly Covid-19 infected patient by plasmapheresis.Transfusion and apheresis science : official journal of the World Apheresis Association : official journal of the European Society for Haemapheresis · 2020Article
- Therapeutic Plasma Exchange: A potential Management Strategy for Critically Ill COVID-19 Patients.Journal of intensive care medicine · 2020Review
- Potential drugs for the treatment of the novel coronavirus pneumonia (COVID-19) in China.Virus research · 2020Review
- Cytokine storm and leukocyte changes in mild versus severe SARS-CoV-2 infection: Review of 3939 COVID-19 patients in China and emerging pathogenesis and therapy concepts.Journal of leukocyte biology · 2020Review
- Application of extracorporeal therapies in critically ill COVID-19 patients.Journal of Zhejiang University. Science. BArticle
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo observe the clinical effect of plasma exchange and tocilizumab in treatment of patients with severe coronavirus disease 2019 (COVID-19).
methodsSix patients with severe COVID-19 admitted in First Affiliated Hospital of Bengbu Medical College from January 25 to February 25, 2020. Three patients were treated with plasma exchange and three patients were treated with tocilizumab. The effect on excessive inflammatory reaction of plasma exchange and tocilizumab was observed.
resultsThe C-reactive protein (CRP) and IL-6 levels were significantly decreased and the lymphocyte and prothrombin time were improved in 3 patients after treatment with plasma exchange; while inflammation level was not significantly decreased, and lymphocyte and prothrombin time did not improve in 3 patients treated with tocilizumab.
conclusionsFor severe COVID-19 patients with strong inflammatory reaction, plasma exchange may be preferred.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.