Evidence map›Paper›PMID 32391647›Full record

ArticleJournal of cellular and molecular medicine2020

Hepatitis B virus-induced hyperactivation of B cells in chronic hepatitis B patients via TLR4.

Yang Li, Shengxia Yin, Yuxin Chen, Quan Zhang, Rui Huang, Bei Jia, Wei Jie, Kefang Yao, Jian Wang, Xin Tong and 2 more

Open access · goldAbstract read
In one paragraph

Article in Journal of cellular and molecular medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.3field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 17 citations in OpenAlex.

  1. Article
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  7. Plerixafor and resatorvid inhibit hepatitis B virusFrontiers in cellular and infection microbiology · 2023
    Article
  8. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 1 institution in 1 country.

Yang LiDepartment of Infectious Diseases, Nanjing Drum Tower Hospital, Nanjing University Medical School, Nanjing, China.
Shengxia YinDepartment of Infectious Diseases, Nanjing Drum Tower Hospital, Nanjing University Medical School, Nanjing, China.
Yuxin ChenDepartment of Laboratory Medicine, Nanjing Drum Tower Hospital, Nanjing University Medical School, Nanjing, China.
Quan ZhangDepartment of Experimental Medicine, Nanjing Drum Tower Hospital, Nanjing University Medical School, Nanjing, China.
Rui HuangDepartment of Infectious Diseases, Nanjing Drum Tower Hospital, Nanjing University Medical School, Nanjing, China.
Bei JiaDepartment of Infectious Diseases, Nanjing Drum Tower Hospital, Nanjing University Medical School, Nanjing, China.
Wei JieDepartment of Infectious Diseases, Nanjing Drum Tower Hospital, Nanjing University Medical School, Nanjing, China.
Kefang YaoDepartment of Infectious Diseases, Nanjing Drum Tower Hospital, Nanjing University Medical School, Nanjing, China.
Jian WangDepartment of Infectious Diseases, Nanjing Drum Tower Hospital, Nanjing University Medical School, Nanjing, China.
Xin TongDepartment of Infectious Diseases, Nanjing Drum Tower Hospital, Nanjing University Medical School, Nanjing, China.
Yong LiuDepartment of Experimental Medicine, Nanjing Drum Tower Hospital, Nanjing University Medical School, Nanjing, China.ORCID 0000-0002-8420-7302
Chao WuDepartment of Infectious Diseases, Nanjing Drum Tower Hospital, Nanjing University Medical School, Nanjing, China.ORCID 0000-0002-1657-010X
Nanjing Drum Tower Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

B cell hyperactivation and functional impairment were identified from patients with chronic hepatitis B virus (CHB) infection; however, the underlying mechanism remains unknown. Here, we aim to elucidate the mechanisms responsible for B cell hyperactivation during HBV infection. Peripheral CD19

Indexed as

AnimalsB-LymphocytesCase-Control StudiesCell ProliferationDisease Models, AnimalGene Expression ProfilingGene Expression RegulationGene OntologyGenome, HumanHepatitis B, ChronicHepatitis B VaccinesHepatitis B virusHeterozygoteHumansLymphocyte ActivationMice, Inbred C57BLHepatitis B VaccinesMyeloid Differentiation Factor 88NF-kappa BToll-Like Receptor 4B cell hyperactivationchronic hepatitis BNF-κB pathwayTLR4

Identifiers

PMID32391647
PMCPMC7294113
OpenAlexW3023430216

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.