ArticleACS omega2020
Contribution of Crystal Lattice Energy on the Dissolution Behavior of Eutectic Solid Dispersions.
Article in ACS omega, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed.
- Duality of Simplicity and Accuracy in QSPR: A Machine Learning Framework for Predicting Solubility of Selected Pharmaceutical Acids in Deep Eutectic Solvents.Molecules (Basel, Switzerland) · 2025Article
- An Investigation into the Effect of Maltitol, Sorbitol, and Xylitol on the Formation of Carbamazepine Solid Dispersions Through Thermal Processing.Pharmaceutics · 2025Article
- Thermodynamic and Structural Characterization of a Mechanochemically Synthesized Pyrazinamide-Acetylsalicylic-Acid Eutectic Mixture.Pharmaceuticals (Basel, Switzerland) · 2025Article
- Hollow Salt Prepared Through Spray Drying with Alginate Enhances Salinity Perception to Reduce Sodium Intake.Foods (Basel, Switzerland) · 2024Article
- Simple preparation and greatly improved oral bioavailability: The supersaturated drug delivery system of quercetin based on PVP K30.Drug delivery and translational research · 2024Article
- Cocrystal Prediction of Nifedipine Based on the Graph Neural Network and Molecular Electrostatic Potential Surface.AAPS PharmSciTech · 2024Article
- General Commentary: A Tribute to Professor Kenneth R. Morris - Scientist, Teacher, Mentor, Friend…and Underappreciated Academic Arborist.Pharmaceutical research · 2023Article
- Saquinavir-Piperine Eutectic Mixture: Preparation, Characterization, and Dissolution Profile.Pharmaceutics · 2023Article
- Pharmacotechnical Evaluation by SeDeM Expert System to Develop Orodispersible Tablets.AAPS PharmSciTech · 2022Article
- Design of Ascorbic Acid Eutectic Mixtures With Sugars to Inhibit Oxidative Degradation.Frontiers in chemistry · 2022Article
- Article
- Brain Delivery of Curcumin Through Low-Intensity Ultrasound-Induced Blood-Brain Barrier Opening via Lipid-PLGA Nanobubbles.International journal of nanomedicine · 2021Article
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In the literature, it is reported that eutectics lead to the enhanced dissolution of a poorly soluble compound. However, the solubility theory suggests that since crystal structures of two components are unchanged that all else being equal, the dissolution rates of a fused mixture (FM) should be the same as a physical mixture (PM). The influence of crystal lattice energy on dissolution profiles was investigated using the PM and FM. Experimental phase diagrams constructed using differential scanning calorimetry data were compared with those theoretically derived. Deviation of the experimental phase diagram curves from the theoretical model indicates the nonideal behavior of both systems (ibuprofen/poly(ethylene glycol)-6000 and acetaminophen/caffeine). Both the binary systems showed an increase in the dissolution rate of the PM and FM. However, the dissolution from the PM was comparable with the FM's dissolution profile. The theoretical solubility calculations using the modified solubility equation showed that the use of the eutectic temperature instead of the drug's melting point should give a 3-4-fold increase in drug solubility. However, the correlation between dissolution and solubility calculation showed that the FM did not improve the dissolution when compared with the respective PM's dissolution profile. The proposed explanation is that the unchanged crystal lattice energy in eutectics still limits the solubility and therefore the dissolution rate.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.