Evidence map›Paper›PMID 32391369›Full record

SynthesisFrontiers in medicine2020

Use of Corticosteroids in Coronavirus Disease 2019 Pneumonia: A Systematic Review of the Literature.

Nicola Veronese, Jacopo Demurtas, Lin Yang, Roberto Tonelli, Mario Barbagallo, Pierluigi Lopalco, Erik Lagolio, Stefano Celotto, Damiano Pizzol, Liye Zou and 5 more

Open access · goldAbstract readSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Frontiers in medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 101 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
101citing papers in PubMed, 6 pooled it
5.0field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

101 citing papers in PubMed, 6 syntheses or guidelines pooled it, 202 citations in OpenAlex.

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41 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 11 institutions in 5 countries.

Nicola VeroneseGeriatric Unit, Department of Internal Medicine and Geriatrics, University of Palermo, Palermo, Italy.
Jacopo DemurtasClinical and Experimental Medicine PhD Program, University of Modena and Reggio Emilia, Modena, Italy.
Lin YangDepartment of Cancer Epidemiology and Prevention Research, Cancer Control Alberta, Alberta Health Services, Calgary, AB, Canada.
Roberto TonelliClinical and Experimental Medicine PhD Program, University of Modena and Reggio Emilia, Modena, Italy.
Mario BarbagalloGeriatric Unit, Department of Internal Medicine and Geriatrics, University of Palermo, Palermo, Italy.
Pierluigi LopalcoDepartment Translational Research and New Technologies in Medicine and Surgery, University of Pisa, Pisa, Italy.
Erik LagolioEmergency Medicine (A&E) - Asl2 - H Santa Corona, Pietra Ligure and First Aid, H Santa Maria Misericordia, Albenga, Italy.
Stefano CelottoPrimary Care Department, Azienda Sanitaria Universitaria Friuli Centrale, Udine, Italy.
Damiano PizzolItalian Agency for Development Cooperation, Khartoum, Sudan.
Liye ZouExercise and Mental Health Laboratory, Shenzhen University, Shenzhen, China.
Mark A TullySchool of Health Sciences, Institute of Mental Health Sciences, Ulster University, Newtownabbey, United Kingdom.
Petre Cristian IlieResearch and Innovation Department, The Queen Elizabeth Hospital Foundation Trust, King's Lynn, United Kingdom.
Mike TrottThe Cambridge Centre for Sport and Exercise Sciences, Anglia Ruskin University, Cambridge, United Kingdom.
Guillermo F López-SánchezFaculty of Sport Sciences, University of Murcia, Murcia, Spain.
Lee SmithThe Cambridge Centre for Sport and Exercise Sciences, Anglia Ruskin University, Cambridge, United Kingdom.
Anglia Ruskin University · GBUniversity of Palermo · ITAlberta Health Services · CAAzienda Usl Toscana Centro · ITInstitute of Mental Health · GBOspedale Santa Corona · ITQueen Elizabeth Hospital King's Lynn NHS Foundation Trust · GBShenzhen University · CNUniversidad de Murcia · ESUniversity of Modena and Reggio Emilia · ITUniversity of Pisa · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The aim was to investigate the effectiveness of glucocorticoid therapy in patients with COVID-19. A systematic search of the literature across nine databases was conducted from inception until 15th March 2020, following the PRISMA guidelines. Patients with a validated diagnosis of COVID-19 and using corticosteroids were included, considering all health outcomes. Four studies with 542 Chinese participants were included. Two studies reported negative findings regarding the use of corticosteroids in patients with COVID-19, i.e., corticosteroids had a detrimental impact on clinical outcomes. One study reported no significant association between the use of corticosteroids and clinical outcomes. However, one study, on 201 participants with different stages of pneumonia due to COVID-19, found that in more severe forms, the administration of methylprednisolone significantly reduced the risk of death by 62%. The literature to date does not fully support the routine use of corticosteroids in COVID-19, but some findings suggest that methylprednisolone could lower mortality rate in more severe forms of the condition.

Indexed as

ARDScoronaviruscorticosteroidsCOVID-19methylprednisolonepneumoniaSARS-Cov-2

Identifiers

PMID32391369
PMCPMC7193030
OpenAlexW3017352783

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.