ReviewFrontiers in bioengineering and biotechnology2020
Recent Advances and Promises in Nitrile Hydratase: From Mechanism to Industrial Applications.
Review in Frontiers in bioengineering and biotechnology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed.
- Sulfur source-driven global remodeling of gene expression in the fuel-biodesulfurizingApplied and environmental microbiology · 2026Article
- Biodegradation of Neonicotinoid Insecticides Thiacloprid and Thiamethoxam by Microorganisms: Metabolic Process, Metabolic Enzymes and Toxicity Assessments of their Metabolites.Current microbiology · 2025Review
- A Versatile Protein Scaffold Engineered for the Hierarchical Assembly of Robust and Highly Active Enzymes.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Microbial degradation mechanisms of the neonicotinoids acetamiprid and flonicamid and the associated toxicity assessments.Frontiers in microbiology · 2024Review
- Non-Native Site-Selective Enzyme Catalysis.Chemical reviews · 2023Review
- A Proterozoic microbial origin of extant cyanide-hydrolyzing enzyme diversity.Frontiers in microbiology · 2023Article
- Genome-resolved metagenomic analysis of Great Amazon Reef System sponge-associated Latescibacterota bacteria and their potential contributions to the host sponge and reef.Frontiers in microbiomes · 2023Article
- An unprecedented palladium-arsenic catalytic cycle for nitriles hydration.Frontiers in chemistry · 2023Article
- Screening and characterization of a nitrilase with significant nitrile hydratase activity.Biotechnology letters · 2022Article
- Direct Reduction of NO to NInorganic chemistry · 2022Article
- Insight into the broadened substrate scope of nitrile hydratase by static and dynamic structure analysis.Chemical science · 2022Article
- Review
- Identification of an Intermediate Species along the Nitrile Hydratase Reaction Pathway by EPR Spectroscopy.Biochemistry · 2021Article
- Computational Design of Nitrile Hydratase fromMolecules (Basel, Switzerland) · 2020Article
- Functional Expression and Characterization of a Panel of Cobalt and Iron-Dependent Nitrile Hydratases.Molecules (Basel, Switzerland) · 2020Article
- Microbial metabolism marvels: a comprehensive review of microbial drug transformation capabilities.Gut microbesReview
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3 authors.
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No grant is acknowledged in the PubMed record.
Abstract
Nitrile hydratase (NHase, EC 4.2.1.84) is one type of metalloenzyme participating in the biotransformation of nitriles into amides. Given its catalytic specificity in amide production and eco-friendliness, NHase has overwhelmed its chemical counterpart during the past few decades. However, unclear catalytic mechanism, low thermostablity, and narrow substrate specificity limit the further application of NHase. During the past few years, numerous studies on the theoretical and industrial aspects of NHase have advanced the development of this green catalyst. This review critically focuses on NHase research from recent years, including the natural distribution, gene types, posttranslational modifications, expression, proposed catalytic mechanism, biochemical properties, and potential applications of NHase. The developments of NHase described here are not only useful for further application of NHase, but also beneficial for the development of the fields of biocatalysis and biotransformation.
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