ArticleJournal of intensive care2020
Low-chloride- versus high-chloride-containing hypertonic solution for the treatment of subarachnoid hemorrhage-related complications: The ACETatE (A low ChloriE hyperTonic solution for brain Edema) randomized trial.
Article in Journal of intensive care, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. It is linked to trial NCT03204955 (Low-chloride Versus High-chloride Containing Hypertonic Solution for the Treatment of Subarachnoid Hemorrhage-Related Complications), which is not on this map. Cited by 25 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Low-chloride Versus High-chloride Containing Hypertonic Solution for the Treatment of Subarachnoid Hemorrhage-Related Complications
Who cites it
25 citing papers in PubMed, 51 citations in OpenAlex.
- An Update on Osmotherapy in Acute Brain Injury: Current and Emerging Strategies.Journal of clinical medicine · 2026Review
- Korean Society of Nephrology 2025 Evidence-Based Clinical Practice Guideline for Continuous Kidney Replacement Therapy.Electrolyte & blood pressure : E & BP · 2026Review
- Korean Society of Nephrology 2025 evidence-based clinical practice guideline for continuous kidney replacement therapy.Kidney research and clinical practice · 2026Article
- Changes in serum sodium during an external ventricular drain weaning in patients with subarachnoid hemorrhage.Frontiers in neurology · 2026Article
- Maintenance and resuscitation fluids for brain injury: keep them salty and not too sweet but mind the kidney.Intensive care medicine · 2025Article
- Which Intravenous Isotonic Fluid Offers Better Outcomes for Patients with a Brain Injury?Neurocritical care · 2025Review
- Should Hypertonic Saline Be Considered for the Treatment of Intracranial Hypertension? A Review of Current Evidence and Clinical Practices.Korean journal of neurotrauma · 2024Review
- Hyperchloremia, a necessary evil in neurocritical care.Critical care (London, England) · 2023Article
- Acute kidney injury in neurocritical care.Critical care (London, England) · 2023Review
- Kidney Dysfunction After Traumatic Brain Injury: Pathophysiology and General Management.Neurocritical care · 2023Review
- A Machine Learning Approach for the Prediction of Severe Acute Kidney Injury Following Traumatic Brain Injury.Neurocritical care · 2023Article
- Hypomagnesemia Is Associated with the Acute Kidney Injury in Traumatic Brain Injury Patients: A Pilot Study.Brain sciences · 2023Article
- Utility of frailty as a predictor of acute kidney injury in patients with aneurysmal subarachnoid hemorrhage.Interventional neuroradiology : journal of peritherapeutic neuroradiology, surgical procedures and related neurosciences · 2023Article
- Early Hyperchloremia and Outcomes After Severe Traumatic Brain Injury: Analysis of Resuscitation Outcomes Consortium Hypertonic Saline Trial.Critical care explorations · 2022Article
- Increase in chloride from baseline is independently associated with mortality in intracerebral hemorrhage patients admitted to intensive care unit: A retrospective study.Journal of intensive medicine · 2022Article
- Fluid Stewardship of Maintenance Intravenous Fluids.Journal of pharmacy practice · 2022Review
- Acute Kidney Injury at the Neurocritical Care Unit.Neurocritical care · 2022Review
- Experimenting with modifications to consent forms in comparative effectiveness research: understanding the impact of language about financial implications and key information.BMC medical ethics · 2022Article
- A nomogram based on serum cystatin C for predicting acute kidney injury in patients with traumatic brain injury.Renal failure · 2021Observational
- Aneurysmal Subarachnoid Hemorrhage: Trends, Outcomes, and Predictions From a 15-Year Perspective of a Single Neurocritical Care Unit.Neurosurgery · 2021Article
Corrections and comments
- Commented on by
- Erratum issued
Authors and funding
12 authors at 3 institutions in 1 country.
Funding
Abstract
backgroundRecent reports have demonstrated that among patients with subarachnoid hemorrhage (SAH) treated with hypertonic NaCl, resultant hyperchloremia has been associated with the development of acute kidney injury (AKI). We report a trial comparing the effect of two hypertonic solutions with different chloride contents on the resultant serum chloride concentrations in SAH patients, with a primary outcome aimed at limiting chloride elevation.
methodsA low ChloridE hyperTonic solution for brain Edema (ACETatE) trial is a single-center, double-blinded, double-dummy, randomized pilot trial comparing bolus infusions of 23.4% NaCl and 16.4% NaCl/Na-acetate for the treatment of cerebral edema in patients with SAH. Randomization occurred when patients developed hyperchloremia (serum Cl
resultsWe enrolled 59 patients, of which 32 developed hyperchloremia and required hyperosmolar treatment. 15 patients were randomized to the 23.4% NaCl group, and 17 patients were randomized to the 16.4% NaCl/Na-acetate group. Although serum chloride levels increased similarly in both groups, the NaCl/Acetate group showed a significantly lower Cl
conclusionsOur pilot trial showed the feasibility and safety of replacing 23.4% NaCl infusions with 16.4% NaCl/Na-acetate infusions to treat cerebral edema in patients with SAH. The degree of hyperchloremia was similar in the two groups. 16.4% NaCl/Na-acetate infusions led to lower Cl
trial registrationclinicaltrials.gov # NCT03204955, registered on 6/28/2017.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.