Evidence map›Paper›PMID 32390870›Full record

ArticleFrontiers in physiology2020

Functional Microbial Responses to Alcohol Abstinence in Patients With Alcohol Use Disorder.

Bei Gao, Atoosa Emami, Rongrong Zhou, Sonja Lang, Yi Duan, Yanhan Wang, Lu Jiang, Rohit Loomba, David A Brenner, Peter Stärkel and 1 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in physiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
1.0field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 16 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Cyclic Nucleotide Phosphodiesterases in Alcohol Use Disorders: Involving Gut Microbiota.The international journal of neuropsychopharmacology · 2023
    Article
  5. Review
  6. Article
  7. Article
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  10. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 2 countries.

Bei GaoDepartment of Medicine, University of California, San Diego, San Diego, CA, United States.
Atoosa EmamiDepartment of Medicine, University of California, San Diego, San Diego, CA, United States.
Rongrong ZhouDepartment of Medicine, University of California, San Diego, San Diego, CA, United States.
Sonja LangDepartment of Medicine, University of California, San Diego, San Diego, CA, United States.
Yi DuanDepartment of Medicine, University of California, San Diego, San Diego, CA, United States.
Yanhan WangDepartment of Medicine, University of California, San Diego, San Diego, CA, United States.
Lu JiangDepartment of Medicine, University of California, San Diego, San Diego, CA, United States.
Rohit LoombaDepartment of Medicine, University of California, San Diego, San Diego, CA, United States.
David A BrennerDepartment of Medicine, University of California, San Diego, San Diego, CA, United States.
Peter StärkelSt. Luc University Hospital, Université Catholique de Louvain, Brussels, Belgium.
Bernd SchnablDepartment of Medicine, University of California, San Diego, San Diego, CA, United States.
University of California, San Diego · USVA San Diego Healthcare System · USUCLouvain · BE

Funding

The Southernearch Center for ALPD and CirrhosisP50AA011999 · NIAAA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI HIDEKAZU TSUKAMOTO · 1999 to 2026
$45.8M
San Diego Digestive Diseases Research CenterP30DK120515 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI LARS ECKMANN, Bernd G. Schnabl · 2019 to 2026
$10.8M
The Role of the Intestinal Mycobiome in Alcoholic Liver DiseaseR01AA024726 · NIAAA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Bernd G. Schnabl · 2018 to 2026
$3.9M
Microbiome and intestinal innate immune response in alcoholic liver diseaseR01AA020703 · NIAAA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI SCHNABL, BERND G. · 2011 to 2020
$3.6M
Microbiome as therapeutic target in alcoholic hepatitisU01AA026939 · NIAAA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI FOUTS, DERRICK E, SCHNABL, BERND G. · 2018 to 2022
$1.7M
BLRD VA I01 BX004594NIAAA NIH HHS P50 AA011999NIAAA NIH HHS R01 AA020703NIAAA NIH HHS R01 AA024726NIAAA NIH HHS U01 AA026939NIDDK NIH HHS P30 DK120515
6 · The paper itself

Abstract

Excessive alcohol consumption is associated with hepatic steatosis and dysregulation of the gut microbiota in patients with alcohol use disorder (AUD). However, how gut microbiota responds when patients stop drinking has not been well studied. In this study, we use shotgun metagenomic sequencing to elucidate the alterations in the functional capacity of gut microbiota in patients with AUD when they stop drinking for 2-weeks. Sensitive microbial pathways to alcohol abstinence were identified in AUD patients. Further, we found the functional microbial responses to alcohol abstinence were different in AUD patients with different degree of hepatic steatosis. Our results provide insights into the link between functional alterations of the gut microbiota and steatosis associated with alcohol consumption.

Indexed as

AUDCAPmetagenomicsmicrobiomesteatosis

Identifiers

PMID32390870
PMCPMC7193112
OpenAlexW3020263489

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.