Evidence map›Paper›PMID 32390858›Full record

ArticleFrontiers in physiology2020

Isoproterenol-Dependent Activation of TRPM7 Protects Against Neurotoxin-Induced Loss of Neuroblastoma Cells.

Yuyang Sun, Amrita Kamat, Brij B Singh

Open access · goldAbstract read
In one paragraph

Article in Frontiers in physiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.7field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 9 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Review
  5. Article
  6. Magnesium and the Brain: A Focus on Neuroinflammation and Neurodegeneration.International journal of molecular sciences · 2022
    Review
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Yuyang SunDepartment of Periodontics, School of Dentistry, University of Texas Health Science Center at San Antonio, San Antonio, TX, United States.
Amrita KamatDepartment of Periodontics, School of Dentistry, University of Texas Health Science Center at San Antonio, San Antonio, TX, United States.
Brij B SinghDepartment of Periodontics, School of Dentistry, University of Texas Health Science Center at San Antonio, San Antonio, TX, United States.
The University of Texas Health Science Center at San Antonio · USGeriatric Research Education and Clinical Center · US

Funding

TRPC1, Calcium, and Saliva SecretionR01DE017102 · NIDCR · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI Brij B Singh · 2006 to 2026
$7.5M
NIDCR NIH HHS R01 DE017102
6 · The paper itself

Abstract

Neuronal function and their survival depend on the activation of ion channels. Loss of ion channel function is known to induce neurodegenerative diseases such as Parkinson's that exhibit loss of dopaminergic neurons; however, mechanisms that could limit neuronal loss are not yet fully identified. Our data suggest that neurotoxin-mediated loss of neuroblastoma SH-SY5Y cells is inhibited by the addition of β-adrenergic receptor (β-AR) agonist isoproterenol. The addition of isoproterenol to SHSY-5Y cells showed increased Mg

Indexed as

apoptosiscell survivalMg2+ influxneurodegenerationTRPM7 activationβ-AR

Identifiers

PMID32390858
PMCPMC7193110
OpenAlexW3020716279

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.