ReviewFrontiers in behavioral neuroscience2020
Impulsivity and Compulsivity After Subthalamic Deep Brain Stimulation for Parkinson's Disease.
Review in Frontiers in behavioral neuroscience, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 39 citations in OpenAlex.
- Subthalamic nucleus deep brain stimulation connectivity related to apathy outcomes in Parkinson's disease.Journal of Parkinson's disease · 2026Article
- Nonmotor Symptoms in Parkinson's Disease: Neurophysiology Biomarkers and Neuromodulation Approaches.Stereotactic and functional neurosurgery · 2026Review
- Neuropsychological aspects of impulse control disorders in Parkinson's disease.Frontiers in aging neuroscience · 2026Review
- Impulse Control Disorders and Effort-Based Decision-Making in Parkinson's Disease Patients with Subthalamic Nucleus Deep Brain Stimulation.Movement disorders clinical practice · 2025Article
- Changes in sensor recorded activity patterns and neuropsychiatric symptoms after deep brain stimulation for Parkinson's disease: 5 case reports.BMC neurology · 2025Article
- Zona incerta: from Parkinson's disease to addiction.Frontiers in neural circuits · 2025Article
- Subthalamic control of impulsive actions: insights from deep brain stimulation in Parkinson's disease.Brain : a journal of neurology · 2024Review
- A Computational Model of Deep Brain Stimulation for Parkinson's Disease Tremor and Bradykinesia.Brain sciences · 2024Article
- Double dissociation of dopamine and subthalamic nucleus stimulation on effortful cost/benefit decision making.Current biology : CB · 2024Article
- Deep brain stimulation of globus pallidus internus and subthalamic nucleus in Parkinson's disease: a multicenter, retrospective study of efficacy and safety.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2024Article
- Uncovering the neurophysiology of mood, motivation and behavioral symptoms in Parkinson's disease through intracranial recordings.NPJ Parkinson's disease · 2023Review
- Impulse Control Disorders in the Polish Population of Patients with Parkinson's Disease.Medicina (Kaunas, Lithuania) · 2023Article
- Toward Personalized Deep Brain Stimulation for Obsessive-Compulsive Disorder.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2023Article
- Stimulation of non-motor subthalamic nucleus impairs selective response inhibition via prefrontal connectivity.Brain communications · 2023Article
- Dynamic control of decision and movement speed in the human basal ganglia.Nature communications · 2022Article
- Review
- Predictors of short-term impulsive and compulsive behaviour after subthalamic stimulation in Parkinson disease.Journal of neurology, neurosurgery, and psychiatry · 2021Article
- Distinct roles of dorsal and ventral subthalamic neurons in action selection and cancellation.Neuron · 2021Article
- Global Cerebral Ischemia in Male Long Evans Rats Impairs Dopaminergic/ΔFosB Signalling in the Mesocorticolimbic Pathway Without Altering Delay Discounting Rates.Frontiers in behavioral neuroscience · 2021Article
- Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Impulsivity and compulsivity are prominent non-motor problems in Parkinson's disease (PD). Despite 20 years of research, there is still an ongoing debate as to whether subthalamic deep brain stimulation (STN DBS) for PD exacerbates or improves these symptoms. Here, we review how STN DBS affects clinical symptoms and neurocognitive aspects of impulsivity and compulsivity. When comparing patients post- to pre-surgery, in the majority of studies STN DBS for PD is associated with a decrease in clinically diagnosed impulse-control disorders and disorders of compulsivity. To avoid confounds, such as post-surgical decreases in dopaminergic medication doses, comparisons can also be made between DBS "On" versus "Off" conditions. These experimentally assayed effects of STN DBS with respect to neurocognitive aspects of impulsivity and compulsivity are more mixed. STN DBS improves behavioral flexibility without impairing negative feedback learning, delay discounting, or inhibitory control, as long as stimulation is restricted to the dorsal STN. However, STN DBS may drive impulsive actions when a subject is faced with competing choices. We discuss how motivated responses may be either enhanced or impaired by STN DBS depending on engagement of dorsal or ventral STN-mediated circuits. Future studies should combine structural and functional circuit measures with behavioral testing in PD patients on and off medication and stimulation. A more sophisticated understanding of how to modulate cortico-striatal-thalamo-cortical loops will increase the likelihood that these circuit manipulation techniques can successfully be applied to a wider range of neuropsychiatric disorders.
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