Evidence map›Paper›PMID 32390806›Full record

ReviewFrontiers in neural circuits2020

Light Up the Brain: The Application of Optogenetics in Cell-Type Specific Dissection of Mouse Brain Circuits.

Candice Lee, Andreanne Lavoie, Jiashu Liu, Simon X Chen, Bao-Hua Liu

Open access · goldAbstract readReview
In one paragraph

Review in Frontiers in neural circuits, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.

0numbers the graph read from it
0cells of the map it votes in
34citing papers in PubMed
3.9field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

34 citing papers in PubMed, 69 citations in OpenAlex.

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  19. Neuronal Spiking Responses to Direct Electrical Microstimulation in the Human Cortex.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Candice LeeDepartment of Cellular and Molecular Medicine, University of Ottawa, Ottawa, ON, Canada.
Andreanne LavoieDepartment of Biology, University of Toronto Mississauga, Mississauga, ON, Canada.
Jiashu LiuDepartment of Biology, University of Toronto Mississauga, Mississauga, ON, Canada.
Simon X ChenDepartment of Cellular and Molecular Medicine, University of Ottawa, Ottawa, ON, Canada.
Bao-Hua LiuDepartment of Biology, University of Toronto Mississauga, Mississauga, ON, Canada.
University of Toronto · CAUniversity of Ottawa · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The exquisite intricacies of neural circuits are fundamental to an animal's diverse and complex repertoire of sensory and motor functions. The ability to precisely map neural circuits and to selectively manipulate neural activity is critical to understanding brain function and has, therefore been a long-standing goal for neuroscientists. The recent development of optogenetic tools, combined with transgenic mouse lines, has endowed us with unprecedented spatiotemporal precision in circuit analysis. These advances greatly expand the scope of tractable experimental investigations. Here, in the first half of the review, we will present applications of optogenetics in identifying connectivity between different local neuronal cell types and of long-range projections with both

Indexed as

AnimalsBrainBrain ChemistryCerebral CortexHumansMiceMice, TransgenicNerve NetOptogeneticsSynapsesGABAergic neuronsneural circuit functionneural circuits and behaviorneural connectivityoptogenetics

Identifiers

PMID32390806
PMCPMC7193678
OpenAlexW3020071629

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.