Trial reportStroke2020
Network Efficiency Mediates the Relationship Between Vascular Burden and Cognitive Impairment: A Diffusion Tensor Imaging Study in UK Biobank.
Trial report in Stroke, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
28 citing papers in PubMed, 1 synthesis or guideline pooled it, 47 citations in OpenAlex.
- Functional connectivity changes in cerebral small vessel disease - a systematic review of the resting-state MRI literature.BMC medicine · 2021Pooled it
- A cross-sectional and longitudinal study of changes in complex networks related to brain function in temporal lobe epilepsy patients treated with levetiracetam intervention therapy.Brain imaging and behavior · 2026Article
- Analysis of cognitive function trajectories and influencing factors in elderly patients with ischemic stroke: a prospective longitudinal study.Frontiers in aging neuroscience · 2026Article
- Altered static and dynamic effective connectivity in patients with type 2 diabetes mellitus with and without microvascular complications.European journal of medical research · 2025Article
- Interrelationships of Social Determinants with Cognition, Vascular Health, and Physical Functioning.Alzheimer's & dementia. Behavior & socioeconomics of aging · 2025Article
- Investigating the impact of electroconvulsive therapy on brain networks and sleep: an observational study protocol.BMJ open · 2025Article
- The influencing factors of cognitive impairment in elderly individuals in Chengdu city: a cross-sectional study based on AD8.BMC geriatrics · 2025Article
- Large inter-arm systolic blood pressure difference is associated with cognitive impairment in older adults: a cross-sectional study in rural southwest China.Frontiers in aging neuroscience · 2025Article
- Peak width of skeletonized mean diffusivity mediates the relationship between cerebral small vessel disease burden and cognitive impairment in community-dwelling older adults.Brain communications · 2025Article
- Effects of Vascular Risk Factors on the White Matter Network Architecture of the Brain.Neuroscience bulletin · 2024Article
- Hypertension, Neurodegeneration, and Cognitive Decline.Hypertension (Dallas, Tex. : 1979) · 2024Review
- Microvascular Dysfunction and Whole-Brain White Matter Connectivity: The Maastricht Study.Journal of the American Heart Association · 2024Article
- Distinct and Overlapping Metabolites Associated with Visual Impairment and Cognitive Impairment.Journal of Alzheimer's disease reports · 2024Article
- A structural heart-brain axis mediates the association between cardiovascular risk and cognitive function.Imaging neuroscience (Cambridge, Mass.) · 2024Article
- Functional MRI brain state occupancy in the presence of cerebral small vessel diseaseImaging neuroscience (Cambridge, Mass.) · 2024Article
- Effect of continuous theta burst stimulation on the glymphatic system, brain network and cognitive function in patients with cerebral small vessel disease.Frontiers in human neuroscience · 2024Article
- C-Reactive protein and cognition: Mediation analyses with brain morphology in the UK Biobank.Brain, behavior, & immunity - health · 2023Article
- Physical fitness, cognition, and structural network efficiency of brain connections across the lifespan.Neuropsychologia · 2023Article
- Genetic architecture of the white matter connectome of the human brain.Science advances · 2023Article
- Rupture discrimination of multiple small (< 7 mm) intracranial aneurysms based on machine learning-based cluster analysis.BMC neurology · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 2 countries.
Funding
Abstract
Background and Purpose- Cerebrovascular disease contributes to age-related cognitive decline, but the mechanisms underlying this phenomenon remain incompletely understood. We hypothesized that vascular risk factors would lead to cognitive impairment through the disruption of brain white matter network efficiency. Methods- Participants were 19 346 neurologically healthy individuals from UK Biobank that underwent diffusion MRI and cognitive testing (mean age=62.6). Global efficiency, a measure of network integration, was calculated from white matter networks constructed using deterministic diffusion tractography. First, we determined whether demographics (age, sex, ethnicity, socioeconomic status, and education), vascular risk factors (hypertension, hypercholesterolemia, diabetes mellitus, smoking, body mass index), and white matter hyperintensities were related to global efficiency using multivariate linear regression. Next, we used structural equation modeling to model a multiple regression. The dependent variable was a latent cognition variable using all cognitive data, while independent variables were a latent factor including all vascular risk factors (vascular burden), demographic variables, white matter hyperintensities, and global efficiency. Finally, we used mediation analysis to determine whether global efficiency explained the relationship between vascular burden and cognition. Results- Hypertension and diabetes mellitus were consistently associated with reduced global efficiency even after controlling for white matter hyperintensities. Structural equation models revealed that vascular burden was associated with cognition (
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.