Evidence map›Paper›PMID 32390525›Full record

ArticleJournal of cardiovascular pharmacology and therapeutics2020

Hydrogen Sulfide Therapy Suppresses Cofilin-2 and Attenuates Ischemic Heart Failure in a Mouse Model of Myocardial Infarction.

Khoa Nguyen, Vinh Q Chau, Adolfo G Mauro, David Durrant, Stefano Toldo, Antonio Abbate, Anindita Das, Fadi N Salloum

Registry-linked trialOpen access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of cardiovascular pharmacology and therapeutics, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07353606 (Determination of Cofilin-2), which is not on this map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
1.2field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07353606 naactive not recruitingnot on this mapstarted 2024, after this paper: background citation

Determination of Cofilin-2 (rs80358250) and Lactoferrin (rs1126478) Genetic Polymorphism and Change in Their Protein Levels Before and After Non-surgical Periodontal Therapy in Periodontitis Patients With and Without Coronary Heart Disease - An Interventional Study.

TypeinterventionalSponsorMeenakshi Ammal Dental College and HospitalRan2024 to 2026Enrolled84ConditionsPeriodontitis, Chronic Periodontitis (Disorder), Coronary Heart DiseaseArmsScaling and root planing
3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 22 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Article
  6. Article
  7. The interplay of hydrogen sulfide and microRNAs in cardiovascular diseases: insights and future perspectives.Mammalian genome : official journal of the International Mammalian Genome Society · 2024
    Review
  8. Review
  9. Article
  10. Article
  11. Review
  12. Role of Hydrogen Sulfide in Oral Disease.Oxidative medicine and cellular longevity · 2022
    Review
  13. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Khoa NguyenDivision of Cardiology, Department of Internal Medicine, VCU Pauley Heart Center, Virginia Commonwealth University, Richmond, VA, USA.
Vinh Q ChauDivision of Cardiology, Department of Internal Medicine, VCU Pauley Heart Center, Virginia Commonwealth University, Richmond, VA, USA.
Adolfo G MauroDivision of Cardiology, Department of Internal Medicine, VCU Pauley Heart Center, Virginia Commonwealth University, Richmond, VA, USA.
David DurrantDivision of Cardiology, Department of Internal Medicine, VCU Pauley Heart Center, Virginia Commonwealth University, Richmond, VA, USA.
Stefano ToldoDivision of Cardiology, Department of Internal Medicine, VCU Pauley Heart Center, Virginia Commonwealth University, Richmond, VA, USA.
Antonio AbbateDivision of Cardiology, Department of Internal Medicine, VCU Pauley Heart Center, Virginia Commonwealth University, Richmond, VA, USA.
Anindita DasDivision of Cardiology, Department of Internal Medicine, VCU Pauley Heart Center, Virginia Commonwealth University, Richmond, VA, USA.
Fadi N SalloumDivision of Cardiology, Department of Internal Medicine, VCU Pauley Heart Center, Virginia Commonwealth University, Richmond, VA, USA.ORCID 0000-0002-8947-9315
Virginia Commonwealth University · US

Funding

Research Supplement to Promote Diversity in Health Related ResearchUL1TR002649 · NCATS · VIRGINIA COMMONWEALTH UNIVERSITY · PI MOELLER, FREDERICK GERARD · 2018 to 2022
$19.1M
Hydrogen Sulfide for Prevention and Treatment of Ischemic Heart FailureR01HL133167 · NHLBI · VIRGINIA COMMONWEALTH UNIVERSITY · PI SALLOUM, FADI N · 2016 to 2020
$1.9M
Relaxin Signaling in Post-MI Cardiac Inflammation, Adverse Remodeling and FailureR01HL142281 · NHLBI · VIRGINIA COMMONWEALTH UNIVERSITY · PI SALLOUM, FADI N · 2018 to 2020
$1.2M
NCATS NIH HHS UL1 TR002649NHLBI NIH HHS R01 HL133167NHLBI NIH HHS R01 HL142281
6 · The paper itself

Abstract

aimsHydrogen sulfide (H METHODS AND

resultsAdult male mice underwent myocardial infarction (MI) by coronary artery ligation after baseline echocardiography. Following MI, mice were treated with Na

conclusionNa

Indexed as

AnimalsApoptosisCofilin 2Disease Models, AnimalDown-RegulationHeart FailureHydrogen SulfideInflammasomesMaleMice, Inbred C57BLMicroRNAsMyocardial InfarctionMyocardiumNLR Family, Pyrin Domain-Containing 3 ProteinSulfidesVentricular Function, LeftCfl2 protein, mouseCofilin 2Hydrogen SulfideInflammasomesMicroRNAsMIRN21 microRNA, mouseNLR Family, Pyrin Domain-Containing 3 ProteinNlrp3 protein, mousesodium sulfideSulfidescardiac functioncofilin-2hydrogen sulfideinflammasomeischemic heart failure

Identifiers

PMID32390525
PMCPMC7365756
OpenAlexW3022169180

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.