Evidence map›Paper›PMID 32390512›Full record

ArticleAmerican journal of physiology. Renal physiology2020

Developmental loss, but not pharmacological suppression, of renal carbonic anhydrase 2 results in pyelonephritis susceptibility.

John Ketz, Vijay Saxena, Samuel Arregui, Ashley Jackson, George J Schwartz, Takafumi Yagisawa, Robert L Fairchild, David S Hains, Andrew L Schwaderer

Open access · bronzeAbstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in American journal of physiology. Renal physiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.8field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 9 citations in OpenAlex.

  1. Review
  2. The immune mechanisms of the urinary tract against infections.Frontiers in cellular and infection microbiology · 2025
    Review
  3. Intercalated cell function, kidney innate immunity, and urinary tract infections.Pflugers Archiv : European journal of physiology · 2024
    Review
  4. Uropathogen and host responses in pyelonephritis.Nature reviews. Nephrology · 2023
    Review
  5. Human neutrophil peptides 1-3 protect the murine urinary tract from uropathogenicProceedings of the National Academy of Sciences of the United States of America · 2022
    Article
  6. Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 1 country.

John KetzCenter for Clinical and Translational Medicine, The Research Institute at Nationwide Children's Hospital, Columbus, Ohio.
Vijay SaxenaDivision of Pediatric Nephrology, Department of Pediatrics, Indiana University, Indianapolis, Indiana.
Samuel ArreguiDivision of Pediatric Nephrology, Department of Pediatrics, Indiana University, Indianapolis, Indiana.
Ashley JacksonCenter for Clinical and Translational Medicine, The Research Institute at Nationwide Children's Hospital, Columbus, Ohio.
George J SchwartzDivision of Nephrology, Department of Pediatrics, University of Rochester Medical Center, Rochester, New York.
Takafumi YagisawaDepartment of Inflammation and Immunity, Cleveland Clinic Foundation, Cleveland, Ohio.
Robert L FairchildDepartment of Inflammation and Immunity, Cleveland Clinic Foundation, Cleveland, Ohio.
David S HainsDivision of Pediatric Nephrology, Department of Pediatrics, Indiana University, Indianapolis, Indiana.
Andrew L SchwadererDivision of Pediatric Nephrology, Department of Pediatrics, Indiana University, Indianapolis, Indiana.
Indiana University – Purdue University Indianapolis · USCleveland Clinic · USNationwide Children's Hospital · USUniversity of Rochester Medical Center · US

Funding

The interface between critical acid-base mediators and the renal bacterial defenseR01DK106286 · NIDDK · RESEARCH INST NATIONWIDE CHILDREN'S HOSP · PI HAINS, DAVID SULLIVAN, SCHWADERER, ANDREW LAWRENCE · 2015 to 2018
$1.6M
HHS | NIH | National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) P01Ai087586NIDDK NIH HHS R01 DK106286
6 · The paper itself

Abstract

Carbonic anhydrase II knockout (

Indexed as

AcetazolamideAcidosisAnimalsCarbonic Anhydrase IICarbonic Anhydrase InhibitorsDisease Models, AnimalEscherichia coli InfectionsGene Expression Regulation, DevelopmentalGenetic Predisposition to DiseaseImmunity, InnateKidneyKidney TransplantationMice, Inbred C57BLMice, KnockoutPyelonephritisReceptor, InsulinAcetazolamideCarbonic Anhydrase IICarbonic Anhydrase InhibitorsReceptor, InsulinS100A11 protein, mouseS100 Proteinsacidosiscollecting ductinnate immunityurinary tract infection

Identifiers

PMID32390512
PMCPMC7311712
OpenAlexW3021377266

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.